Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F22%3A00013855" target="_blank" >RIV/75010330:_____/22:00013855 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.science.org/doi/10.1126/scitranslmed.abn3253" target="_blank" >https://www.science.org/doi/10.1126/scitranslmed.abn3253</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/scitranslmed.abn3253" target="_blank" >10.1126/scitranslmed.abn3253</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

Popis výsledku v původním jazyce

As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.

Název v anglickém jazyce

Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

Popis výsledku anglicky

As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science Translational Medicine

ISSN

1946-6234

e-ISSN

1946-6242

Svazek periodika

14

Číslo periodika v rámci svazku

642

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

eabn3253

Kód UT WoS článku

000789484400004

EID výsledku v databázi Scopus

2-s2.0-85128938472