Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021-2022 and emergence of novel B3-derived lineages, ENPEN multicentre study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F24%3A00014792" target="_blank" >RIV/75010330:_____/24:00014792 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/jid/article/230/4/e917/7637136#google_vignette" target="_blank" >https://academic.oup.com/jid/article/230/4/e917/7637136#google_vignette</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/infdis/jiae154" target="_blank" >10.1093/infdis/jiae154</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021-2022 and emergence of novel B3-derived lineages, ENPEN multicentre study

Popis výsledku v původním jazyce

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021–2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0–5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.

Název v anglickém jazyce

Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021-2022 and emergence of novel B3-derived lineages, ENPEN multicentre study

Popis výsledku anglicky

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021–2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0–5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Infectious Diseases

ISSN

0022-1899

e-ISSN

1537-6613

Svazek periodika

230

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

e917-e928

Kód UT WoS článku

001409226200001

EID výsledku v databázi Scopus

2-s2.0-85206595718