Powerhouse down: Complex II dissociation in the respiratory chain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00441825" target="_blank" >RIV/86652036:_____/14:00441825 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mito.2014.06.001" target="_blank" >http://dx.doi.org/10.1016/j.mito.2014.06.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mito.2014.06.001" target="_blank" >10.1016/j.mito.2014.06.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Powerhouse down: Complex II dissociation in the respiratory chain

Popis výsledku v původním jazyce

Complex II of the respiratory chain (RC) recently emerged as a prominent regulator of cell death. In both cancer cells as well as neurodegenerative diseases, mutations in subunits have been found along with other genetic alterations indirectly affectingthis complex. Anticancer compounds were developed that target complex II and cause cell death in a tumor-specific way. Our mechanistic understanding of how complex Ills activated for cell death induction has recently been made clearer in recent studies,the results of which are covered in this review. This protein assembly is specifically activated for cell death via the dissociation of its SDHA and SDHB subunits from the membrane-anchoring proteins through pH change or mitochondrial Ca2+ influx. The SDH activity contained in the SDHA/SDHB subcomplex remains intact and then generates, in an uncontrolled fashion, excessive amounts of reactive oxygen species (ROS) for cell death. Future studies on this mitochondrial complex will further e

Název v anglickém jazyce

Powerhouse down: Complex II dissociation in the respiratory chain

Popis výsledku anglicky

Complex II of the respiratory chain (RC) recently emerged as a prominent regulator of cell death. In both cancer cells as well as neurodegenerative diseases, mutations in subunits have been found along with other genetic alterations indirectly affectingthis complex. Anticancer compounds were developed that target complex II and cause cell death in a tumor-specific way. Our mechanistic understanding of how complex Ills activated for cell death induction has recently been made clearer in recent studies,the results of which are covered in this review. This protein assembly is specifically activated for cell death via the dissociation of its SDHA and SDHB subunits from the membrane-anchoring proteins through pH change or mitochondrial Ca2+ influx. The SDH activity contained in the SDHA/SDHB subcomplex remains intact and then generates, in an uncontrolled fashion, excessive amounts of reactive oxygen species (ROS) for cell death. Future studies on this mitochondrial complex will further e

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mitochondrion

ISSN

1567-7249

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

Part A SI

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

20-28

Kód UT WoS článku

000346624700004

EID výsledku v databázi Scopus

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