Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00444484" target="_blank" >RIV/86652036:_____/14:00444484 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-394625-6.00008-8" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-394625-6.00008-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-394625-6.00008-8" target="_blank" >10.1016/B978-0-12-394625-6.00008-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy

Popis výsledku v původním jazyce

Cancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy.

Název v anglickém jazyce

Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy

Popis výsledku anglicky

Cancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Progress in Molecular Biology and Translational Science

ISSN

1877-1173

e-ISSN

—

Svazek periodika

2014

Číslo periodika v rámci svazku

127

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

211-227

Kód UT WoS článku

000341461400008

EID výsledku v databázi Scopus

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