Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00481119" target="_blank" >RIV/86652036:_____/17:00481119 - isvavai.cz</a>

Výsledek na webu

<a href="https://patents.google.com/patent/CN105452265B/en" target="_blank" >https://patents.google.com/patent/CN105452265B/en</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

Popis výsledku v původním jazyce

The subject of the invention are new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivativesnof tamoxifen where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixturen(MitoTAX). Alkyl triphenylphosphonium derivatives oftamoxifen have the general formula (I), where n=8 to 12 and where Z is selectednfrom the group of organic salts or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the generalnformula IA, where n = 6 to l 0 and where Z has the above mentioned meaning. These compounds are applicable for the treatment ofnneoplastic disease, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases according to theninvention contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I)nand/or IA or their corresponding salts of tertiary amine.

Název v anglickém jazyce

Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

Popis výsledku anglicky

The subject of the invention are new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivativesnof tamoxifen where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixturen(MitoTAX). Alkyl triphenylphosphonium derivatives oftamoxifen have the general formula (I), where n=8 to 12 and where Z is selectednfrom the group of organic salts or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the generalnformula IA, where n = 6 to l 0 and where Z has the above mentioned meaning. These compounds are applicable for the treatment ofnneoplastic disease, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases according to theninvention contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I)nand/or IA or their corresponding salts of tertiary amine.

Druh

P - Patent

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Číslo patentu nebo vzoru

CN105452265

Vydavatel

CN002 -

Název vydavatele

Patent Office - State Intellectual Property Office of the Peoples` Republic of China (SIPO)

Místo vydání

Beijing

Stát vydání

CN - Čínská lidová republika

Datum přijetí

10. 5. 2017

Název vlastníka

J. Neužil, Biotechnologický ústav AV ČR, v. v. i., Smart Brain s.r.o., KKCG AG

Způsob využití

A - Výsledek využívá pouze poskytovatel

Druh možnosti využití

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence