Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00508206" target="_blank" >RIV/86652036:_____/17:00508206 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/emm2016153" target="_blank" >https://www.nature.com/articles/emm2016153</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/emm.2016.153" target="_blank" >10.1038/emm.2016.153</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy

Popis výsledku v původním jazyce

Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell-cell communication by transferring nucleic acids and proteins to target cells and tissues. Recently, MicroRNAs (miRs) and their delivery in exosomes have been implicated in physiological and pathological processes. Tumor-delivered miRs, interacting with stromal cells in the tumor microenvironment, modulate tumor progression, angiogenesis, metastasis and immune escape. Altered cell metabolism is one of the hallmarks of cancer. A number of different types of tumor rely on mitochondrial metabolism by triggering adaptive mechanisms to optimize their oxidative phosphorylation in relation to their substrate supply and energy demands. Exogenous exosomes can induce metabolic reprogramming by restoring the respiration of cancer cells and supress tumor growth. The exosomal miRs involved in the modulation of cancer metabolism may be potentially utilized for better diagnostics and therapy.

Název v anglickém jazyce

Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy

Popis výsledku anglicky

Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell-cell communication by transferring nucleic acids and proteins to target cells and tissues. Recently, MicroRNAs (miRs) and their delivery in exosomes have been implicated in physiological and pathological processes. Tumor-delivered miRs, interacting with stromal cells in the tumor microenvironment, modulate tumor progression, angiogenesis, metastasis and immune escape. Altered cell metabolism is one of the hallmarks of cancer. A number of different types of tumor rely on mitochondrial metabolism by triggering adaptive mechanisms to optimize their oxidative phosphorylation in relation to their substrate supply and energy demands. Exogenous exosomes can induce metabolic reprogramming by restoring the respiration of cancer cells and supress tumor growth. The exosomal miRs involved in the modulation of cancer metabolism may be potentially utilized for better diagnostics and therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Molecular Medicine

ISSN

1226-3613

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

JAN 2017

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

e285

Kód UT WoS článku

000393674100005

EID výsledku v databázi Scopus

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