IL-6 and its role in IgA nephropathy development
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00558971" target="_blank" >RIV/86652036:_____/22:00558971 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/22:73614603
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S1359610122000235?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359610122000235?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cytogfr.2022.04.001" target="_blank" >10.1016/j.cytogfr.2022.04.001</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
IL-6 and its role in IgA nephropathy development
Popis výsledku v původním jazyce
IL-6 is considered one of the well characterized cytokines exhibiting homeostatic, pro-and anti-inflammatory activities, depending on the receptor variant and the induced intracellular cis-or trans-signaling responses. IL 6-activated pathways are involved in the regulation of cell proliferation, survival, differentiation, and cell metabolism changes.Deviations in IL-6 levels or abnormal response to IL-6 signaling are associated with several autoimmune diseases including IgA nephropathy (IgAN), one of most frequent primary glomerulonephritis worldwide. IgAN is associated with increased plasma concentration of IL-6 and increased plasma concentration of aberrantly galactosylated IgA1 immunoglobulin (Gd-IgA1). Gd-IgA1 is specifically recognized by autoantibodies, leading to the formation of circulating immune complexes (CIC) with nephritogenic potential, since CIC deposited in the glomerular mesangium induce mesangial cells proliferation and glomerular injury. Infection of the upper respiratory or digestive tract enhances IL-6 production and in IgAN patients is often followed by the macroscopic hematuria.This review recapitulates general aspects of IL-6 signaling and summarizes experimental evidences about IL-6 involvement in the etiopathogenesis of IgA nephropathy through the production of Gd-IgA1 and regulation of mesangial cell proliferation.
Název v anglickém jazyce
IL-6 and its role in IgA nephropathy development
Popis výsledku anglicky
IL-6 is considered one of the well characterized cytokines exhibiting homeostatic, pro-and anti-inflammatory activities, depending on the receptor variant and the induced intracellular cis-or trans-signaling responses. IL 6-activated pathways are involved in the regulation of cell proliferation, survival, differentiation, and cell metabolism changes.Deviations in IL-6 levels or abnormal response to IL-6 signaling are associated with several autoimmune diseases including IgA nephropathy (IgAN), one of most frequent primary glomerulonephritis worldwide. IgAN is associated with increased plasma concentration of IL-6 and increased plasma concentration of aberrantly galactosylated IgA1 immunoglobulin (Gd-IgA1). Gd-IgA1 is specifically recognized by autoantibodies, leading to the formation of circulating immune complexes (CIC) with nephritogenic potential, since CIC deposited in the glomerular mesangium induce mesangial cells proliferation and glomerular injury. Infection of the upper respiratory or digestive tract enhances IL-6 production and in IgAN patients is often followed by the macroscopic hematuria.This review recapitulates general aspects of IL-6 signaling and summarizes experimental evidences about IL-6 involvement in the etiopathogenesis of IgA nephropathy through the production of Gd-IgA1 and regulation of mesangial cell proliferation.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/EF16_025%2F0007397" target="_blank" >EF16_025/0007397: Centrum pro Rekombinantní biotechnologie a imunoterapeutika</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Cytokine & Growth Factor Reviews
ISSN
1359-6101
e-ISSN
1879-0305
Svazek periodika
66
Číslo periodika v rámci svazku
AUG 2022
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
14
Strana od-do
1-14
Kód UT WoS článku
000819259100001
EID výsledku v databázi Scopus
2-s2.0-85129566894