Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F24%3A00604158" target="_blank" >RIV/86652036:_____/24:00604158 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-081423-093942" target="_blank" >https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-081423-093942</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1146/annurev-neuro-081423-093942" target="_blank" >10.1146/annurev-neuro-081423-093942</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

Popis výsledku v původním jazyce

Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.

Název v anglickém jazyce

Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

Popis výsledku anglicky

Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA23-05963S" target="_blank" >GA23-05963S: Transkripční a epigenetická regulace ve vývoji sluchových neuronů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annual Review of Neuroscience

ISSN

0147-006X

e-ISSN

1545-4126

Svazek periodika

47

Číslo periodika v rámci svazku

February 15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

1-20

Kód UT WoS článku

001293203100001

EID výsledku v databázi Scopus

2-s2.0-85197356232