Targeting Mitochondrial Integrity as a New Senolytic Strategy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F25%3A00647613" target="_blank" >RIV/86652036:_____/25:00647613 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/25:00085900 RIV/00216208:11310/25:10506954 RIV/60461373:22330/25:43931476

Výsledek na webu

<a href="https://www.aginganddisease.org/EN/10.14336/AD.2024.1100" target="_blank" >https://www.aginganddisease.org/EN/10.14336/AD.2024.1100</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14336/AD.2024.1100" target="_blank" >10.14336/AD.2024.1100</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Targeting Mitochondrial Integrity as a New Senolytic Strategy

Popis výsledku v původním jazyce

Aging, characterized by accumulation of senescent cells, is a driving factor of various age-related diseases. These conditions pose significant health risks globally due to their increasing prevalence and serious complications. Reduction of senescent cells therefore represents a promising strategy promoting healthy aging. Here we demonstrate that targeting tamoxifen to mitochondria via triphenyl and tricyclohexyl phosphine selectively eliminates senescent cells. Our findings show a complex effect of mitochondrially targeted tamoxifen on mitochondrial function and integrity of senescent cells, including inhibition of oxidative phosphorylation and activity of respiratory complex IV. These changes result in activation of ferroptosis as the major mode of cell death, which results in rejuvenation of tissues. Targeting mitochondria of senescent cells represents a general senolytic strategy and may extend the healthspan and improve the quality of life in aging populations.

Název v anglickém jazyce

Targeting Mitochondrial Integrity as a New Senolytic Strategy

Popis výsledku anglicky

Aging, characterized by accumulation of senescent cells, is a driving factor of various age-related diseases. These conditions pose significant health risks globally due to their increasing prevalence and serious complications. Reduction of senescent cells therefore represents a promising strategy promoting healthy aging. Here we demonstrate that targeting tamoxifen to mitochondria via triphenyl and tricyclohexyl phosphine selectively eliminates senescent cells. Our findings show a complex effect of mitochondrially targeted tamoxifen on mitochondrial function and integrity of senescent cells, including inhibition of oxidative phosphorylation and activity of respiratory complex IV. These changes result in activation of ferroptosis as the major mode of cell death, which results in rejuvenation of tissues. Targeting mitochondria of senescent cells represents a general senolytic strategy and may extend the healthspan and improve the quality of life in aging populations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30227 - Geriatrics and gerontology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aging and Disease

ISSN

2152-5250

e-ISSN

2152-5250

Svazek periodika

16

Číslo periodika v rámci svazku

FEB 2025

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

3638-3648

Kód UT WoS článku

001423770000001

EID výsledku v databázi Scopus

2-s2.0-105024112923