Molecular Cascades That Build and Connect Auditory Neurons from Hair Cells to the Auditory Cortex

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F25%3A00647809" target="_blank" >RIV/86652036:_____/25:00647809 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.scientificarchives.com/article/molecular-cascades-that-build-and-connect-auditory-neurons-from-hair-cells-to-the-auditory-cortex" target="_blank" >https://www.scientificarchives.com/article/molecular-cascades-that-build-and-connect-auditory-neurons-from-hair-cells-to-the-auditory-cortex</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33696/Neurol.6.114" target="_blank" >10.33696/Neurol.6.114</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Cascades That Build and Connect Auditory Neurons from Hair Cells to the Auditory Cortex

Popis výsledku v původním jazyce

Understanding the development of the auditory system is crucial for uncovering the molecular origins of hearing and its related disorders. During this development, spiral ganglion neurons extend peripheral fibers to cochlear hair cells and central projections to the cochlear nuclei, setting up a tonotopic map that connects the ear to the brainstem, enabling frequency-specific sound perception. This sensory information is then integrated bilaterally through a relay involving the superior olivary complex, lateral lemniscus, inferior colliculus, medial geniculate body, and the auditory cortex. While anatomical connectivity has been well-documented, recent advancements have revealed gene regulatory networks that coordinate the specification, differentiation, and connectivity of auditory neurons. In this review, we examine the molecular cascades guiding auditory system development, emphasizing transcriptional hierarchies and lineage determinants. Insights into these mechanisms enhance our understanding of auditory circuit formation and provide a critical foundation for therapeutic strategies aimed at addressing congenital and acquired hearing loss.

Název v anglickém jazyce

Molecular Cascades That Build and Connect Auditory Neurons from Hair Cells to the Auditory Cortex

Popis výsledku anglicky

Understanding the development of the auditory system is crucial for uncovering the molecular origins of hearing and its related disorders. During this development, spiral ganglion neurons extend peripheral fibers to cochlear hair cells and central projections to the cochlear nuclei, setting up a tonotopic map that connects the ear to the brainstem, enabling frequency-specific sound perception. This sensory information is then integrated bilaterally through a relay involving the superior olivary complex, lateral lemniscus, inferior colliculus, medial geniculate body, and the auditory cortex. While anatomical connectivity has been well-documented, recent advancements have revealed gene regulatory networks that coordinate the specification, differentiation, and connectivity of auditory neurons. In this review, we examine the molecular cascades guiding auditory system development, emphasizing transcriptional hierarchies and lineage determinants. Insights into these mechanisms enhance our understanding of auditory circuit formation and provide a critical foundation for therapeutic strategies aimed at addressing congenital and acquired hearing loss.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA23-05963S" target="_blank" >GA23-05963S: Transkripční a epigenetická regulace ve vývoji sluchových neuronů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Experimental Neurology

ISSN

2692-2819

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

111-120

Kód UT WoS článku

—

EID výsledku v databázi Scopus

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