Lung cancer risk from occupational and environmental radon and role of smoking

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652052%3A_____%2F11%3A%230000025" target="_blank" >RIV/86652052:_____/11:#0000025 - isvavai.cz</a>

Výsledek na webu

<a href="http://oem.bmj.com/content/68/Suppl_1/A87.2.abstract?sid=2819f88b-4901-4f59-a180-c6337eb705b7" target="_blank" >http://oem.bmj.com/content/68/Suppl_1/A87.2.abstract?sid=2819f88b-4901-4f59-a180-c6337eb705b7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/oemed-2011-100382.285" target="_blank" >10.1136/oemed-2011-100382.285</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lung cancer risk from occupational and environmental radon and role of smoking

Popis výsledku v původním jazyce

The study is based on two Czech cohorts of U miners and people exposed to high levels of radon in houses. including 1107 and 240 cases of lung cancer. Individual smoking data were collected for most of subjects (68% and 75%, respectively). The relative risk is evaluated in dependence on cumulated exposure with effect modification by time since exposure and smoking. The excess relative risk per unit exposure from earlier periods of exposure (20 years and more) is about 1/3 in comparison to recent exposures (5-19 years). Smoking specific estimates of excess relative risk per unit exposure were 3-5 times higher among never smokers in both studies. The interaction of radon and smoking is evaluated by geometric mixture models. When smoking specific doses tothe lungs and modifying effect of time since exposure are used, the combined effect of radon and smoking is close to the additive model.

Název v anglickém jazyce

Lung cancer risk from occupational and environmental radon and role of smoking

Popis výsledku anglicky

The study is based on two Czech cohorts of U miners and people exposed to high levels of radon in houses. including 1107 and 240 cases of lung cancer. Individual smoking data were collected for most of subjects (68% and 75%, respectively). The relative risk is evaluated in dependence on cumulated exposure with effect modification by time since exposure and smoking. The excess relative risk per unit exposure from earlier periods of exposure (20 years and more) is about 1/3 in comparison to recent exposures (5-19 years). Smoking specific estimates of excess relative risk per unit exposure were 3-5 times higher among never smokers in both studies. The interaction of radon and smoking is evaluated by geometric mixture models. When smoking specific doses tothe lungs and modifying effect of time since exposure are used, the combined effect of radon and smoking is close to the additive model.

Druh

O - Ostatní výsledky

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

—

Projekt

<a href="/cs/project/NS10596" target="_blank" >NS10596: Zdravotní rizika vyplývající z expozice radonu v pracovním a životním prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů