PUMA – pooled uranium miners analysis: cohort profile

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652052%3A_____%2F20%3AN0000063" target="_blank" >RIV/86652052:_____/20:N0000063 - isvavai.cz</a>

Výsledek na webu

<a href="https://oem.bmj.com/content/77/3/194" target="_blank" >https://oem.bmj.com/content/77/3/194</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/oemed-2019-105981" target="_blank" >10.1136/oemed-2019-105981</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PUMA – pooled uranium miners analysis: cohort profile

Popis výsledku v původním jazyce

Epidemiological studies of underground miners have provided clear evidence that inhalation of radon decay products causes lung cancer. Moreover, these studies have served as a quantitative basis for estimation of radon-associated excess lung cancer risk. However, questions remain regarding the effects of exposure to the low levels of radon decay products typically encountered in contemporary occupational and environmental settings on the risk of lung cancer and other diseases, and on the modifiers of these associations. These issues are of central importance for estimation of risks associated with residential and occupational radon exposures. The Pooled Uranium Miner Analysis (PUMA) study represents the largest study of uranium miners conducted to-date, encompassing 124,507 miners, 4.51 million person-years at risk, and 54,462 deaths, including 7,825 deaths due to lung cancer. Data available include individual annual estimates of exposure to radon decay products, demographic and employment history information on each worker, and information on vital status, date of death, and cause of death. Some, but not all, cohorts also have individual information on cigarette smoking, external gamma radiation exposure, and non-radiological occupational exposures. In summary, PUMA provides opportunities to evaluate new research questions and to conduct analyses to assess potential health risks associated with uranium mining that have greater statistical power than can be achieved with any single cohort.

Název v anglickém jazyce

PUMA – pooled uranium miners analysis: cohort profile

Popis výsledku anglicky

Epidemiological studies of underground miners have provided clear evidence that inhalation of radon decay products causes lung cancer. Moreover, these studies have served as a quantitative basis for estimation of radon-associated excess lung cancer risk. However, questions remain regarding the effects of exposure to the low levels of radon decay products typically encountered in contemporary occupational and environmental settings on the risk of lung cancer and other diseases, and on the modifiers of these associations. These issues are of central importance for estimation of risks associated with residential and occupational radon exposures. The Pooled Uranium Miner Analysis (PUMA) study represents the largest study of uranium miners conducted to-date, encompassing 124,507 miners, 4.51 million person-years at risk, and 54,462 deaths, including 7,825 deaths due to lung cancer. Data available include individual annual estimates of exposure to radon decay products, demographic and employment history information on each worker, and information on vital status, date of death, and cause of death. Some, but not all, cohorts also have individual information on cigarette smoking, external gamma radiation exposure, and non-radiological occupational exposures. In summary, PUMA provides opportunities to evaluate new research questions and to conduct analyses to assess potential health risks associated with uranium mining that have greater statistical power than can be achieved with any single cohort.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Occupational and Environmental Medicine

ISSN

1351-0711

e-ISSN

1470-7926

Svazek periodika

77

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

194–200

Kód UT WoS článku

000518866100011

EID výsledku v databázi Scopus

2-s2.0-85079151022