Criticality accident dosimetry with human blood: The dicentric chromosome assay and the neutron activation as complementary techniques

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652052%3A_____%2F25%3AN0000013" target="_blank" >RIV/86652052:_____/25:N0000013 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/25:00382561

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1350448724003135" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1350448724003135</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.radmeas.2024.107365" target="_blank" >10.1016/j.radmeas.2024.107365</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Criticality accident dosimetry with human blood: The dicentric chromosome assay and the neutron activation as complementary techniques

Popis výsledku v původním jazyce

In the case of a criticality accident, human blood can be used for dosimetry employing the dicentric chromosome assay (DCA) and the neutron activation technique. An experimental comparison of these different methods was performed within a trial where blood samples were irradiated in a mixed gamma-neutron radiation field generated by a training nuclear reactor. Blind doses applied within the trial were in the range relevant to triage. The total dose was evaluated based on the established DCA dose-effect curve for the mixed gamma-neutron radiation field. Gamma and neutron doses were evaluated by means of an iteration technique utilizing previously derived neutron and gamma radiation specific dose-effect relationships for DCA and the known ratio between neutron and gamma doses that was found via reference dosimetry and calculations. Considering scenarios where the ratio is unknown, the Bayesian approach was also applied and compared with the outputs of the iteration technique. Neutron dose was also determined on the basis of the neutron activation of sodium occurring in blood and blood serum via the nuclear reaction 23Na(n,γ)24Na. Neutron spectrum specific activity-to-dose conversion factors were derived for both blood serum and whole blood. As regards neutron dose, results of the DCA and the neutron activation technique were in a good agreement. Gamma doses obtained using the DCA were also in an acceptable agreement with gamma dose reference values. The neutron activation technique is faster and less laborious, but its accuracy is dependent on the knowledge of neutron spectrum. The iteration technique applied within the DCA proved to be successful but its applicability is conditioned by the known ratio between neutron and gamma doses. The Bayesian approach led to satisfactory dose estimates for the applied range of a priory values of neutron to gamma dose ratios. The DCA and neutron activation technique used together may complement each other, however, additional methods may be needed to obtain all the necessary data.

Název v anglickém jazyce

Criticality accident dosimetry with human blood: The dicentric chromosome assay and the neutron activation as complementary techniques

Popis výsledku anglicky

In the case of a criticality accident, human blood can be used for dosimetry employing the dicentric chromosome assay (DCA) and the neutron activation technique. An experimental comparison of these different methods was performed within a trial where blood samples were irradiated in a mixed gamma-neutron radiation field generated by a training nuclear reactor. Blind doses applied within the trial were in the range relevant to triage. The total dose was evaluated based on the established DCA dose-effect curve for the mixed gamma-neutron radiation field. Gamma and neutron doses were evaluated by means of an iteration technique utilizing previously derived neutron and gamma radiation specific dose-effect relationships for DCA and the known ratio between neutron and gamma doses that was found via reference dosimetry and calculations. Considering scenarios where the ratio is unknown, the Bayesian approach was also applied and compared with the outputs of the iteration technique. Neutron dose was also determined on the basis of the neutron activation of sodium occurring in blood and blood serum via the nuclear reaction 23Na(n,γ)24Na. Neutron spectrum specific activity-to-dose conversion factors were derived for both blood serum and whole blood. As regards neutron dose, results of the DCA and the neutron activation technique were in a good agreement. Gamma doses obtained using the DCA were also in an acceptable agreement with gamma dose reference values. The neutron activation technique is faster and less laborious, but its accuracy is dependent on the knowledge of neutron spectrum. The iteration technique applied within the DCA proved to be successful but its applicability is conditioned by the known ratio between neutron and gamma doses. The Bayesian approach led to satisfactory dose estimates for the applied range of a priory values of neutron to gamma dose ratios. The DCA and neutron activation technique used together may complement each other, however, additional methods may be needed to obtain all the necessary data.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10304 - Nuclear physics

Projekt

<a href="/cs/project/VK01020052" target="_blank" >VK01020052: Komplex metod biologické a fyzikální retrospektivní dozimetrie pro radiační mimořádné události</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Measurements

ISSN

1350-4487

e-ISSN

1879-0925

Svazek periodika

181

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

107365

Kód UT WoS článku

001392978500001

EID výsledku v databázi Scopus

2-s2.0-85212314204