Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F15%3A00473328" target="_blank" >RIV/86652079:_____/15:00473328 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications
Popis výsledku v původním jazyce
This study was performed in order to obtain polymeric magnetic microparticles based on chitosan, poly(vinyl alcohol) and maghemite as colloidal magnetic nanoparticles. For preparation of particles we used double crosslinking in reverse emulsion procedure. Sodium sulphate (Na2SO4) solution is added for ionic crosslinking of the polymers and glutaraldehyde is used as covalent crosslinking agent. The following preparation parameters were studied: concentration of polymers solution, concentration of surfactants, poly(vinyl alcohol) to chitosan weight ratio, stirring speed, molar ratio between crosslinking agents, polymers to magnetic material weight ratio. The characterization of microparticles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The evaluations of their toxicity together with hemocompatibility tests have shown that these particles exhibit the prerequisite behavior for use in biomedical field, for drug targeting. Also, was studied the behavior of particles in aqueous media, the drug (5-fluorouracil) loading and the kinetic of drug release from the particles, determined that particles behave differently depending on their structural characteristics, composition and morphology.
Název v anglickém jazyce
Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications
Popis výsledku anglicky
This study was performed in order to obtain polymeric magnetic microparticles based on chitosan, poly(vinyl alcohol) and maghemite as colloidal magnetic nanoparticles. For preparation of particles we used double crosslinking in reverse emulsion procedure. Sodium sulphate (Na2SO4) solution is added for ionic crosslinking of the polymers and glutaraldehyde is used as covalent crosslinking agent. The following preparation parameters were studied: concentration of polymers solution, concentration of surfactants, poly(vinyl alcohol) to chitosan weight ratio, stirring speed, molar ratio between crosslinking agents, polymers to magnetic material weight ratio. The characterization of microparticles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The evaluations of their toxicity together with hemocompatibility tests have shown that these particles exhibit the prerequisite behavior for use in biomedical field, for drug targeting. Also, was studied the behavior of particles in aqueous media, the drug (5-fluorouracil) loading and the kinetic of drug release from the particles, determined that particles behave differently depending on their structural characteristics, composition and morphology.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EH - Ekologie – společenstva
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Optoelectronics and Advanced Materials
ISSN
1454-4164
e-ISSN
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Svazek periodika
17
Číslo periodika v rámci svazku
7-8
Stát vydavatele periodika
RO - Rumunsko
Počet stran výsledku
12
Strana od-do
1198-1209
Kód UT WoS článku
000359967600046
EID výsledku v databázi Scopus
2-s2.0-84944261087