Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F20%3A00536338" target="_blank" >RIV/86652079:_____/20:00536338 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14160/20:00117745
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2020.104298" target="_blank" >10.1016/j.bioorg.2020.104298</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Popis výsledku v původním jazyce
Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
Název v anglickém jazyce
Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Popis výsledku anglicky
Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
—
Svazek periodika
104
Číslo periodika v rámci svazku
NOV
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
104298
Kód UT WoS článku
000592397400007
EID výsledku v databázi Scopus
2-s2.0-85091969421