Investigating the phytotoxic effects of binary mixtures of diclofenac and paracetamol on duckweed synergistic or antagonistic interaction?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F25%3A00642523" target="_blank" >RIV/86652079:_____/25:00642523 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/25:00142814

Výsledek na webu

<a href="https://www.scopus.com/pages/publications/105019508850?origin=resultslist" target="_blank" >https://www.scopus.com/pages/publications/105019508850?origin=resultslist</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2025.127295" target="_blank" >10.1016/j.envpol.2025.127295</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigating the phytotoxic effects of binary mixtures of diclofenac and paracetamol on duckweed synergistic or antagonistic interaction?

Popis výsledku v původním jazyce

Mixtures of emerging aquatic contaminants, like diclofenac (DCF) and paracetamol (PCT) commonly occurring in the environment, can exhibit combination effects. Accumulation of drugs in duckweed plants exposed for seven days to DCF + PCT mixtures was similar to that under individual drugs (both 0.2, 2, and 20 mg/L). But the nature of drug interaction in mixtures was ambiguous, even though the toxic impact of DCF was more substantial than that of PCT. Mixtures with a DCF-to-PCT ratio of 1:1 exhibited a synergistic interaction manifested by a decrease (up to 90 %) in plant number, especially in mixtures DCF 2 + PCT 2 and DCF 20 + PCT 20 mg/L. In mixtures with unequal ratios (1:10 or 1:100 with a predominance of DCF or PCT), their interaction attenuated with time to additive or even antagonistic. This finding (shift from synergistic to additive interaction) was supported even by changes in the plants' dry weight, leaf area, or photosynthetic pigment content. Similarly, a negligible decrease in photosynthetic performance in plants exposed to the mixtures with unequal ratios supported the mitigation of the drug mixture effect. Both individual drugs and their mixtures of 2 and 20 mg/L elevated the production of reactive oxygen species. The antioxidant defence mechanism activity was elevated already by low drug doses (0.2 and 2 mg/L), and the highest contamination (20 mg/L) led to its decrease. Utilizing the number of plants parameter showed that the nature of drug interaction in the mixture is fluctuating, and the causal factors include the ratio of mixture component concentrations and the length of the exposure period.

Název v anglickém jazyce

Investigating the phytotoxic effects of binary mixtures of diclofenac and paracetamol on duckweed synergistic or antagonistic interaction?

Popis výsledku anglicky

Mixtures of emerging aquatic contaminants, like diclofenac (DCF) and paracetamol (PCT) commonly occurring in the environment, can exhibit combination effects. Accumulation of drugs in duckweed plants exposed for seven days to DCF + PCT mixtures was similar to that under individual drugs (both 0.2, 2, and 20 mg/L). But the nature of drug interaction in mixtures was ambiguous, even though the toxic impact of DCF was more substantial than that of PCT. Mixtures with a DCF-to-PCT ratio of 1:1 exhibited a synergistic interaction manifested by a decrease (up to 90 %) in plant number, especially in mixtures DCF 2 + PCT 2 and DCF 20 + PCT 20 mg/L. In mixtures with unequal ratios (1:10 or 1:100 with a predominance of DCF or PCT), their interaction attenuated with time to additive or even antagonistic. This finding (shift from synergistic to additive interaction) was supported even by changes in the plants' dry weight, leaf area, or photosynthetic pigment content. Similarly, a negligible decrease in photosynthetic performance in plants exposed to the mixtures with unequal ratios supported the mitigation of the drug mixture effect. Both individual drugs and their mixtures of 2 and 20 mg/L elevated the production of reactive oxygen species. The antioxidant defence mechanism activity was elevated already by low drug doses (0.2 and 2 mg/L), and the highest contamination (20 mg/L) led to its decrease. Utilizing the number of plants parameter showed that the nature of drug interaction in the mixture is fluctuating, and the causal factors include the ratio of mixture component concentrations and the length of the exposure period.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/QL24010115" target="_blank" >QL24010115: Inovativní produkce speciálních kultur jako zdroje potravin s vysokou dietetickou hodnotou</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Pollution

ISSN

0269-7491

e-ISSN

1873-6424

Svazek periodika

387

Číslo periodika v rámci svazku

Dec.

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

127295

Kód UT WoS článku

001606241200001

EID výsledku v databázi Scopus

2-s2.0-105019508850