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13 347 (0,095s) •

Projekt

Galectins as biomarkers of colorectal cancer (LTC19035)

-acetylhexosaminidases) as well as human galectin-4 necessary as a standard in affinity assays of biosensor based on highly selective and specific interaction between human galectins and prepared oligosaccharides. The pilot...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 4 421 tis. Kč
    • •
  • 4 421 tis. Kč
    • •
  • MŠMT
Projekt

Characterization of interactions of biomacromolecules with biolayers in different conformation states using piezoelectric biosensors (OC 518.30)

; direct measurement of small molecules, competitive and sandwich affinity assays.).Kinetic interactions of immobilized biomolecules with complementary affinity partners as well as the effect of external conditions on confo...

CE - Biochemie

  • 2000 - 2001
    • •
  • 970 tis. Kč
    • •
  • 620 tis. Kč
    • •
  • MŠMT
Projekt

Novel biologics for cancer imaging (GAP301/12/1513)

will generate randomized libraries of ligands based on compact and stable scaffolds and use using the affinity maturation and/or rational design. The high affinity binders against PSMA will be used in proof-of-concept biol...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 11 017 tis. Kč
    • •
  • 11 017 tis. Kč
    • •
  • GA ČR
Projekt

Mono- and multivalent inhibitors of galectin-8 in tumour-associated (lymph)angiogenesis (GF25-16301K)

biocompatible mono- and multivalent carbohydrate-based ligands for selective targeting of galectin-8 (Gal-8) and assess their affinity and selectivity over other human galectins by molecular modeling to reach specific and high-...

Medicinal chemistry

  • 2025 - 2028
    • •
  • 6 480 tis. Kč
    • •
  • 6 480 tis. Kč
    • •
  • GA ČR
Projekt

Functional Assays for Rapid Microbiological Diagnostics of Selected Health-Care Associated Infections (NV19-05-00541)

diagnostic microbiological assays is of utmost importance. Especially, functional transfer. Functional assays for detection of selected bacterial toxins (ToxB of C. difficile and YopT of Y. enterocolitica) using affinity M...

Microbiology

  • 2019 - 2022
    • •
  • 9 063 tis. Kč
    • •
  • 9 063 tis. Kč
    • •
  • MZ
Projekt

Realising the therapeutic potential of novel cardioprotective therapies (LTC18041)

associated with increased galectin-3 expression. High-affinity saccharide ligands based-acetylglucosamine bearing additional functional groups to increase the affinity (avidity will be characteri-zed structurally in detail...

Biochemistry and molecular biology

  • 2018 - 2021
    • •
  • 3 997 tis. Kč
    • •
  • 3 997 tis. Kč
    • •
  • MŠMT
Projekt

Structure-based design of ligands and inhibitors targeting glutamate carboxypeptidase II and its homologs (ME10031)

Development of novel activity assay for GCPII/GCPIII based on fluorescence anisotropy that, in turn, will be exploited for the identification of novel inhibitor in silico and in vitro testing. Structure-based modifications ...

CE - Biochemie

  • 2010 - 2012
    • •
  • 1 947 tis. Kč
    • •
  • 1 947 tis. Kč
    • •
  • MŠMT
Projekt

Multivalent glycopolymers as ligands of lectin-denoted biological targets (LTC17005)

, in particular galectin-3, in biological studies in vitro, namely binding assays and assays in cell cultures. The affinity of glycopolymeric conjugates to lectin targets......

CE - Biochemie

  • 2017 - 2020
    • •
  • 2 791 tis. Kč
    • •
  • 2 791 tis. Kč
    • •
  • MŠMT
Projekt

Library of engineered glycosidases for the preparation of bioactive glycans (LTC20072)

that will afford multivalent glycoconjugates with high affinity (avidity) and possibly also high selectivity for particular galectins. Affinity of prepared glycostructures will be tested by ELISA-type assays and other meth...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 3 997 tis. Kč
    • •
  • 3 997 tis. Kč
    • •
  • MŠMT
Projekt

Regulation of mitochondrial uncoupling proteins by purine nucleotides and hypothetical other physiological regulators. (LZ1K03002)

the inhibitory affinity of UCP1, 2, and 3 for nucleotides and acyl-CoA esters. We will test whether purine nucleotides regulate UCP2 and 3 and whether changes of the assay that some important metabolites lower the affinity...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
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  • 1 007 tis. Kč
    • •
  • 571 tis. Kč
    • •
  • MŠMT
  • 1 - 10 z 13 347