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Projekt

Tumors with no aspartate synthesis a metabolic mystery (GA24-10167S)

Aspartate! It was thought to be clear how cancer cells make this amino acid, essential for their proliferation and tumor growth. Two enzymes, transaminases GOT1 and GOT2, are known to produce aspartate endogenously. But we ...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 9 937 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • GA ČR
Projekt

The estimation of the D, L forms of the aspartic acid in the human tissues as the marker of the age. (NB4753)

The research project deals with the estimation of the ratio of the D,Lforms of the aspartic acid in the correlat. with the age using the GC and HPLC chiral separat. and possible influence of the postmortal changes and anlytic. procedur. on t...

FP - Ostatní lékařské obory

  • 1998 - 2000
    • •
  • 1 796 tis. Kč
    • •
  • 1 572 tis. Kč
    • •
  • MZ
Projekt

Role of aspartic proteinases in nutrient acquisition and starvation of pathogenic yeasts Candida albicans and Candida parapsilosis (GA310/09/1945)

Opportunistic pathogens of the genus Candida produce secreted aspartic aspartic proteinases. They are predicted to play a role in adaptation of Candida spp. to starvation. Interplay of extracellular and intracellular aspartic

EE - Mikrobiologie, virologie

  • 2009 - 2011
    • •
  • 1 677 tis. Kč
    • •
  • 1 677 tis. Kč
    • •
  • GA ČR
Projekt

Induction and inhibition of isoenzymes of the aspartic proteinases secreted by the yeast belonging to the genus Candida (GA303/98/P252)

The Candida yeast cause severe diseases in immunocompromised patients. Aspartic proteinases secreted by the Candida yeast are believed to act as one of the virulence factors: they participate in skin and organ penetration, degradation of cyt...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1998 - 2001
    • •
  • 762 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Projekt

Rational design and synt. of inhibitors of aspartic proteinases from Candida yeasts a way to chemotherapy of opportunistic infections in immunosuppres patients (GA203/95/1028)

CE - Biochemie

  • 1995 - 1997
    • •
  • 700 tis. Kč
    • •
  • 700 tis. Kč
    • •
  • GA ČR
Projekt

Secreted Aspartic Proteinases of Candida spp. targets for drug developing (GA303/98/1612)

Pathogenesis of Candida sp. is strongly dependent on the production of aspartic proteinases secreted by these yeasts into the environment. These proteinases degrade a number of tissue proteins and thus facilitate deep invasion of Candida spp...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1998 - 2000
    • •
  • 2 338 tis. Kč
    • •
  • 2 000 tis. Kč
    • •
  • GA ČR
Projekt

Design of novel peptidic inhibitors of cysteine and aspartic proteases (GP203/01/D008)

inhuman pathology, (2) digestive aspartic proteases of insect pests. Namely with metastasis ofseveral types of tumors. Aspartic protease cathepsin D plays central......

CE - Biochemie

  • 2001 - 2004
    • •
  • 846 tis. Kč
    • •
  • 605 tis. Kč
    • •
  • GA ČR
Projekt

Study of the role of different isoenzymes of aspartic proteases in the virulence of Candida spp. (GA303/04/0432)

of these factors are the secreted aspartic proteinases (Saps) encoded by 10 members of the SAP vacuolar aspartic protease which is poorly characterized. To determine possible......

CE - Biochemie

  • 2004 - 2006
    • •
  • 1 215 tis. Kč
    • •
  • 1 215 tis. Kč
    • •
  • GA ČR
Projekt

Hemoglobinolytic aspartic peptidase IrCD - a member of the gut-associated digestive enzyme complex in the tick I. ricinus (KJB600960911)

Using the model tick Ixodes ricinus, we have recently demonstrated that tick intestinal digestion of host blood is based on gut-associated cysteine and aspartic peptidases. The peptidase spectrum is similar to the digestive cascade/network o...

CE - Biochemie

  • 2009 - 2010
    • •
  • 848 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • AV ČR
Projekt

The introduction of a new method for age estimation based on the evaluation of D,L-forms of aspartic acid in human tissues. (IZ1894)

9F - 9

  • 1994 - 1995
    • •
  • 84 tis. Kč
    • •
  • 168 tis. Kč
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  • MZ
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