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Projekt

New potential cardioprotective agents study of structure-activity relationships in various types of myocardial injury (GA13-15008S)

of dexrazoxane and salicylaldehyde isonicotinoyl hydrazone. Apart from the detailed...

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
  • 10 985 tis. Kč
  • 10 985 tis. Kč
  • GA ČR
Projekt

Cardiovascular, Potentially Cardioprotective and Biotransformational Effects of New Iron Chelating Agents. (GA305/03/1511)

Iron plays a key role in the in vivo formation of oxyradicals, which are considered to be the main factor in the aetiology of many pathologies including anthracycline cardiomyopathy. Ortho-halogenated analogs of pyridoxal benzoyl hydrazone (...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
  • 3 445 tis. Kč
  • 3 445 tis. Kč
  • GA ČR
Projekt

New iron chelators - problems of their cardiovascular, potential cardioprotective and biotransformation effects (GA305/00/0365)

Iron plays a key role in the in vivo formation of oxyradicals, which are considered to be the main factor in the etiology of many pathologies incl. anthracycline cardiomyopathy. Pyridoxal isonicotinoyl hydrazone (PIH) and its analog...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
  • 4 975 tis. Kč
  • 4 495 tis. Kč
  • GA ČR
Projekt

Light driven functional hydrazone and azobenzene based liquid crystalline polymers for photonics. (GC20-22615J)

of the project is utilization of the hydrazone photosensitive moiety in reactive mesogens. The main objectives are to (i) demonstrate that hydrazone structural motif is viable......

Organic chemistry

  • 2020 - 2022
  • 5 420 tis. Kč
  • 5 323 tis. Kč
  • GA ČR
Projekt

NMR studies of some azo dyes (GA203/96/0123)

The aim of this project is the synthesis of some ato dyes and their 15N isotopomers, measurements of kinetics and multinuclear NMR studies (1H, 13C and 15N NMR). quantitative description of ato-hydrazone tantomerism. Two-dimensional NMR spec...

CC - Organická chemie

  • 1996 - 1998
  • 1 270 tis. Kč
  • 1 070 tis. Kč
  • GA ČR
Projekt

Catalysis by transition metal complexes with azine ligands (GA203/97/1157)

of unsymmetrical ligands by condensation of hydrazone and ketone synthons. Complexes...

CA - Anorganická chemie

  • 1997 - 1999
  • 1 237 tis. Kč
  • 797 tis. Kč
  • GA ČR
Projekt

Novel Generation of Polymer Drug Carrier Systems for Site-specific Therapy (IAA4050201)

doxorubicin to the carrier via hydrazone bonds, which are stable in blood but hydrolyzable...

CD - Makromolekulární chemie

  • 2002 - 2006
  • 11 639 tis. Kč
  • 4 846 tis. Kč
  • AV ČR
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