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509 (0,078s)

Výsledek výzkumu

A new colorimetric assay for methionyl aminopeptidases: Examination of the binding of a new class of pseudopeptide analog inhibitors

A direct and convenient spectrophotometric assay has been developed for methionine aminopeptidases. The method employs the hydrolysis of a substrate that is L-Met-pNA. The assay has been used to screen novel pseudopeptide inhibitors...

CC - Organická chemie

  • 2006
  • Jx
Výsledek výzkumu

S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors

Methionyl aminopeptidases (MetAPs) are metallo-dependent proteases responsible for removing of N-terminal methionine residue of peptides and proteins during protein the substrate specificity of three methionyl aminopeptidases

CC - Organická chemie

  • 2012
  • Jx
  • Odkaz
Výsledek výzkumu

Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine

Ligands containing bulky aliphatic P1 residues exhibit a high affinity towards cytosolic leucine aminopeptidase, a bizinc protease of biomedical significance and phosphinic compounds were derivatives of methionine and norleucine as ...

CC - Organická chemie

  • 2011
  • Jx
  • Odkaz
Výsledek výzkumu

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

, methionine aminopeptidase and isocitrate lyase, which are necessary for the maintenance inhibitorsof both mycobacterial and human methionine aminopeptidase and they also affect......

FR - Farmakologie a lékárnická chemie

  • 2012
  • Jx
  • Odkaz
Výsledek výzkumu

Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl)pyrazine-2-carboxamides as inhibitors of mycobacterial methionine aminopeptidase 1

target - mycobacterial methionine aminopeptidase 1 (MtMetAP1). The inhibitory...

Pharmacology and pharmacy

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

Different peptides as substrates of aminopeptidases of salmon eggsin embryogenesis

By means of chromogenic aminopeptidase substrates the levels of several aminopeptidases were monitored in fertilized maturing salmon eggs (Salmon salar). The levels of the enzymes are significantly increasing in the time of final ma...

CE - Biochemie

  • 2006
  • Jx
Výsledek výzkumu

Aminopeptidases of eggs of spiny-cheek crayfish Orconectes limosus (Raf)

Five aminopeptidase were detected in the ripening eggs of crayfish Orconectes limosus (Raf.).

CE - Biochemie

  • 2004
  • D
Výsledek výzkumu

Aminopeptidases of Tricholomae fruit bodies

Peptidase activities in mushroom...

CE - Biochemie

  • 2002
  • D
Výsledek výzkumu

Histochemical study of aminopeptidase M, aminopeptidase A, and gama-glutamyltransferase in the nasal cavity of laboratory rodents and man

FP - Ostatní lékařské obory

  • 1994
  • Jx
Výsledek výzkumu

Aminopeptidases specific for peptides with N-terminal aromatic amino acids in the fruiting bodies of some widespread mushrooms

Aminopeptidases specific for peptides with N-terminal aromatic amino acids in the fruiting bodies of some widespread mushrooms...

CE - Biochemie

  • 2003
  • D
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