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3 031 (0,542s) •

Projekt

Lectins from human pathogens - structure, function, engineering (GA303/09/1168)

of already identified proteins from opportunistic human pathogens and also proteins that will be identified by database search in newly sequenced genomes. Selected proteins determinants.  Crystal structure determination of...

BO - Biofyzika

  • 2009 - 2012
    • •
  • 3 416 tis. Kč
    • •
  • 3 416 tis. Kč
    • •
  • GA ČR
Projekt

Identification of the molecular structure of ligand binding site of melatonin receptor MT2 (GA309/04/0496)

be attributedto the fact that melatonin receptors belong to two distinct classes of proteins, the G-protein coupled receptor family MT and MT, high- affinity melatonin binding to the seven- transmembrane domain (7TM) receptor super...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 929 tis. Kč
    • •
  • 2 929 tis. Kč
    • •
  • GA ČR
Projekt

Using Artificial Intelligence to Design New Bioactive Compounds in the Research of G Protein-Coupled Receptors (GN22-17367O)

G protein-coupled receptors (GPCRs) are a large protein family involved in complex signaling pathways in eukaryotes, some of which are implicated in a large number of diseases. GPCRs are activated by endogenous ligands which makes t...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2022 - 2025
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  • 4 855 tis. Kč
    • •
  • 4 855 tis. Kč
    • •
  • GA ČR
Projekt

Synthesis of new brassinosteroids and study of their interaction with plant and animal receptors (GJ15-08202Y)

derivatives, their docking into the structure of receptor kinase BRI1 and testing expression of proteins involved in cell cycle regulation and apoptosis......

CC - Organická chemie

  • 2015 - 2017
    • •
  • 3 581 tis. Kč
    • •
  • 3 581 tis. Kč
    • •
  • GA ČR
Projekt

Modulation of steroid receptors in human cancer cells by brassinosteroids. (GA19-01383S)

in-silico docking studies. The most active substances in this study will be labeled; iii) protein by SWATH analysis....

Organic chemistry

  • 2019 - 2021
    • •
  • 7 233 tis. Kč
    • •
  • 7 233 tis. Kč
    • •
  • GA ČR
Projekt

Investigating the Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor using Computational Simulations (GA13-21053S)

affinities create two action levels in the protein's response to L-arg. Interpretation of this complex system requires an understanding of the protein's conformational landscape. Molecular dynamics simulations, umbrella sampling, Q...

CF - Fyzikální chemie a teoretická chemie

  • 2013 - 2018
    • •
  • 3 883 tis. Kč
    • •
  • 3 883 tis. Kč
    • •
  • GA ČR
Projekt

Modus operandi of cytokinin-sensing histidine kinases in plants (GA15-19266S)

employment of in silico (bioinformatics, molecular modeling and molecular docking) and experimental (rational protein design, combinatorial saturation mutagenesis and focused......

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 9 576 tis. Kč
    • •
  • 9 576 tis. Kč
    • •
  • GA ČR
Projekt

Investigations into regioselectivity of evolved epoxide hydrolases (GAP207/10/0135)

and substrate docking) will follow. Our research will shed light on the relationship between...

EI - Biotechnologie a bionika

  • 2010 - 2012
    • •
  • 2 507 tis. Kč
    • •
  • 2 507 tis. Kč
    • •
  • GA ČR
Projekt

Effect of protein hydration shell on the stability of protein complexes. (GPP205/12/P729)

Protein-protein interactions are at the basis of almost all cellular processes, but plays an active part in determining the structure and dynamics of both proteins and protein complexes. However, the exact molecula...

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2017
    • •
  • 2 037 tis. Kč
    • •
  • 2 037 tis. Kč
    • •
  • GA ČR
Projekt

Study of the interaction between 14-3-3 protein and regulator of G protein signaling RGS3. (IAA501110801)

protein?dependent regulation of function of RGS3 protein. 14-3-3 proteins are regulatory molecules that bind to other proteins in a phosphorylation dependent manner. RGS proteins function both as GTPase a...

BO - Biofyzika

  • 2008 - 2012
    • •
  • 5 095 tis. Kč
    • •
  • 5 095 tis. Kč
    • •
  • AV ČR
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