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Projekt

The impact of bradykinin B2 receptor gene inactivation in mouse distal tubule on sodium handling in experimental models of hypertension (NT14011)

The kallikrein–kinin system (KKS) has been considered to play a physiological. An integrative role in cross-talk between KKS and other systems such as the renin-angiotensin system (RAS) and nitric oxide (NO) has been suggested. Howe...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
  • 3 103 tis. Kč
  • 3 103 tis. Kč
  • MZ
Projekt

Smart Accelerator 2.0 (EF18_055/0013938)

round of the Smart Accelerator project and to continue in the development of the KK to the fulfillment of key areas of change of the Regional Innovation Strategy of the KK through developers throughout the project, linked to the pr...

Other natural sciences

  • 2020 - 2023
  • 44 266 tis. Kč
  • 0 tis. Kč
  • MŠMT
Projekt

When the half could be equal to the whole Evolution of dosage compensation in squamate reptiles (GA19-19672S)

(ZZ/ZW) and male (XX/XY) heterogamety. However, it is still unknown how particular), birds and advanced snakes (ZZ/ZW). Surprisingly, other amniote lineages have in dosage compensation mechanisms between XX/XY and ZZ/ZW sy...

Zoology

  • 2019 - 2023
  • 7 931 tis. Kč
  • 7 931 tis. Kč
  • GA ČR
Projekt

Turnover of sex chromosomes in the karyotype evolution of Lepidoptera (GA14-22765S)

chromosome constitution, Z0/ZZ (female/male), whereas the advanced Ditrysia and autosomal genes in representatives of the primitive Z0/ZZ and advanced WZ/ZZ systems......

EB - Genetika a molekulární biologie

  • 2014 - 2016
  • 6 825 tis. Kč
  • 6 825 tis. Kč
  • GA ČR
Projekt

Chromosomal and molecular mechanisms of sex determination in Lepidoptera (GA20-13784S)

Moths and butterflies (Lepidoptera) have sex chromosome systems with female heterogamety (WZ/ZZ, Z/ZZ), but the actual mechanism of sex determination is largely unknown. Only recently the primary sex-determining factor was discovere...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2023
  • 12 888 tis. Kč
  • 12 888 tis. Kč
  • GA ČR
Projekt

Diversity of molecular mechanisms of sex determination in moths and butterflies (GA24-11425S)

Moths and butterflies (Lepidoptera) have sex chromosome systems with female heterogamety (WZ/ZZ, Z/ZZ), but the molecular mechanisms of sex determination are poorly understood. The sex-determining pathway is known only in the silkwo...

Genetics and heredity (medical genetics to be 3)

  • 2024 - 2026
  • 11 586 tis. Kč
  • 11 586 tis. Kč
  • GA ČR
Projekt

Evolution of the early phases of sex determination comparative studies on Silene otites, Silene colpophylla and Silene latifolia. (IAA600040801)

We suggest to use three related species of the genus Silene for the study of processes of early phases of sex determination. Although Silene otites and S. colpophylla are closely related species, some data indicate that these species possess differen...

EF - Botanika

  • 2008 - 2011
  • 3 936 tis. Kč
  • 3 936 tis. Kč
  • AV ČR
Projekt

The lizard perspective on mammalian sex chromosomes (GA17-22604S)

Differentiated sex chromosomes are an excellent case of genomic convergence. Despite considerable effort it has not been sufficiently explained why (and whether) sex chromosomes evolve differently in groups with male (XX/XY) versus female (ZZ

EG - Zoologie

  • 2017 - 2021
  • 8 732 tis. Kč
  • 8 663 tis. Kč
  • GA ČR
Projekt

Early evolution of lepidopteran neo-sex chromosomes (GJ20-20650Y)

(Lepidoptera) represent the most speciose lineage with female heterogamety (WZ/ZZ). Unlike in other WZ/ZZ taxa, sex chromosome-autosome fusions are common in Lepidoptera, which......

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2022
  • 8 983 tis. Kč
  • 8 983 tis. Kč
  • GA ČR
Projekt

Driving forces behind the evolution of lepidopteran W chromosomes (GA17-13713S)

Moths and butterflies (Lepidoptera) represent the largest animal group with female heterogamety, i.e. with a WZ/ZZ (or Z0/ZZ) sex chromosome system. The W chromosome is an evolutionary novelty in this successful and species-rich gro...

EB - Genetika a molekulární biologie

  • 2017 - 2019
  • 10 575 tis. Kč
  • 9 600 tis. Kč
  • GA ČR
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