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3 072 (0,207s) •

Projekt

Identification of Endogenous Ligands of the Central Bezodiazepine Receptors in Hepatic Encephalopathy (GA309/93/1120)

ED - Fyziologie

  • 1993 - 1995
    • •
  • 310 tis. Kč
    • •
  • 620 tis. Kč
    • •
  • GA ČR
Projekt

The role of Toll-like receptor signaling in the mechanism of central tolerance (GA19-23154S)

. Mechanisms of central tolerance that are operational in the thymus, robustly limit a self-reactive T cell antigen receptor or their deviation into regulatory T cells (Tregs). Central to these mechanisms are antigen presen...

Immunology

  • 2019 - 2021
    • •
  • 8 619 tis. Kč
    • •
  • 8 178 tis. Kč
    • •
  • GA ČR
Projekt

Library of antibodies recognising proteins involved in neurotransmission that are regulated genetically or functionally (1P05OE183)

prepares sets of antibodies, antibodies agains 8 matabotrophic glutamate receptors, antibodies against protein associated with these receptors, neurotransmitters......

EI - Biotechnologie a bionika

  • 2005 - 2007
    • •
  • 3 437 tis. Kč
    • •
  • 1 655 tis. Kč
    • •
  • MŠMT
Projekt

Structural and functional determinants of NMDA receptor trafficking (GP14-09220P)

N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. Their activation plays a key role is to elucidate mechanisms determining trafficking of NMDA receptors<...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 2 218 tis. Kč
    • •
  • 2 218 tis. Kč
    • •
  • GA ČR
Projekt

Influence of cholesterol on muscarinic receptor signalling (GP305/05/P209)

It has been generally accepted that muscarinic receptors play an important role in mental performance. Central muscarinic neurotransmission declines in the course receptors. For this purpose we shall exploit Chinese hamster...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 1 146 tis. Kč
    • •
  • 1 146 tis. Kč
    • •
  • GA ČR
Projekt

Molecular properties and regulation of glutamate receptor function (GA309/97/0517)

in the vertebrate central nervous systém. In view of the role of glutamate receptors of the present information about glutamate receptors has been gained in studies on cultured and function of glutamate receptors ...

FH - Neurologie, neurochirurgie, neurovědy

  • 1997 - 1999
    • •
  • 3 940 tis. Kč
    • •
  • 1 769 tis. Kč
    • •
  • GA ČR
Projekt

Allosteric regulation of muscarinic acetylcholine receptors (GA309/99/0214)

of muscarinic receptors for acetylcholine, which are responsible for the transfer of information on many synapses in the central and peripheral nervous systems. Previous work and functions of the allosteric binding sites on muscari...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 4 833 tis. Kč
    • •
  • 4 146 tis. Kč
    • •
  • GA ČR
Projekt

Novel abiotic receptors for biologically significant dianions synthesis and properties (GA203/98/0726)

Novel ditopic receptors distinguished by a two-point attachement of peripheral perazacrown or guanidine units to a central rigid platform have been designed. A modular synthetic approach has been devised allowing a gradual scaling-u...

CC - Organická chemie

  • 1998 - 2000
    • •
  • 2 556 tis. Kč
    • •
  • 1 984 tis. Kč
    • •
  • GA ČR
Projekt

Modulation of olfactory pheromonal system by hormone at the central and peripheral level (MEB020719)

1 Determination of the hormonal context of the lepidopteran adults of every sex. 2 Gene expression research with respect to the olfactory perception, reproduction and ecdysteroid titre. 3 Analyze functional of the different chosen actors in the perip...

ED - Fyziologie

  • 2008 - 2008
    • •
  • 50 tis. Kč
    • •
  • 50 tis. Kč
    • •
  • MŠMT
Projekt

The role of GABAB receptors in animal models of tinnitus (GA16-17823S)

and enhanced neural synchrony in the auditory cortex. GABAB receptors are the G protein coupled receptors for GABA, the main inhibitory neurotransmitter in the central nervous system. GABAB receptors are essential...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2020
    • •
  • 5 799 tis. Kč
    • •
  • 5 673 tis. Kč
    • •
  • GA ČR
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