Vše

Co hledáte?

Vše
Projekty
Výsledky výzkumu
Subjekty

Rychlé hledání

  • Projekty podpořené TA ČR
  • Významné projekty
  • Projekty s nejvyšší státní podporou
  • Aktuálně běžící projekty

Chytré vyhledávání

  • Takto najdu konkrétní +slovo
  • Takto z výsledků -slovo zcela vynechám
  • “Takto můžu najít celou frázi”
CS
ČeštinaEnglish

Filtry

1 603 (0,082s) •

Projekt

Molecular basis of canonical Wnt signalling during eye and brain development (GA204/08/1618)

Beta-catenin protein posseses dual function as it is required for cell adhesion as well as for transcriptional regulation in the canonical Wnt signalling pathway. Using the ongoing support from GACR we have investi...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 3 555 tis. Kč
    • •
  • 3 555 tis. Kč
    • •
  • GA ČR
Projekt

Tumor suppressors in the Wnt signaling pathway (GA204/07/1567)

Wnt signaling controls embryonic development and the aberrant activation of the Wnt pathway leads to cancer. In canonical signaling beta-catenin acts with the TCF of the Wnt pathway. HIC1...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 433 tis. Kč
    • •
  • 4 433 tis. Kč
    • •
  • GA ČR
Projekt

Reconstruction of an ancestral chordate organizer the role of Wnt/beta-catenin signaling. (GC15-21285J)

is to investigate the function of Wnt/β-catenin signaling in dorsal axis formation and organizer...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 5 940 tis. Kč
    • •
  • 5 124 tis. Kč
    • •
  • GA ČR
Projekt

Mechanisms regulating normal and leukemic hematopoietic stem cells Deciphering the role of the beta-catenin/Tcf signaling pathway (GA17-02177S)

is abundantly expressed in HSC and that by forming a complex with β-catenin it might, and whether targeting the formation of the β-catenin/Tcf4 complex could serve......

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 6 927 tis. Kč
    • •
  • 6 213 tis. Kč
    • •
  • GA ČR
Projekt

The role of wnt signalling in eye development and lens cell differentiation (GA204/04/1358)

development. Much less is known about the role of another major signalling pathway, Wnt pathway, and its key intracellular mediator, beta-catenin .We decided to use. These transcription factors most likel...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 150 tis. Kč
    • •
  • 3 150 tis. Kč
    • •
  • GA ČR
Projekt

The role of Wnt/beta-catenin signaling during neurogenesis. (GA17-05466S)

Wnt signaling plays an essential role in the development of mammalian CNS. We will investigate the impact of the canonical Wnt pathway both on neuronal/glial differentiation or the Wnt inhibitor Dkk1. Furthermore, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
    • •
  • 5 720 tis. Kč
    • •
  • 5 556 tis. Kč
    • •
  • GA ČR
Projekt

Expression of molecular markers regulating hair follicle development and differentiation of trichogenic tumurs (NR8386)

Finding of molecular changes in expression of smooth-muscle actin, E-cadherin, beta-catenin, c-myc, cyclin D1 and androgen receptor in various hair follicle tumors. Analysis of relations concerning molecules of Wnt signalli...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 054 tis. Kč
    • •
  • 1 025 tis. Kč
    • •
  • MZ
Projekt

Novel components of the Wnt signaling pathway (GA204/04/0532)

-catenin/TCF complexes discriminate between different subsets of all potential WntWnt signaling controls numerous developmental processes and the aberrant activation of Wnt genes is also implicated in deregulated c...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 100 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • GA ČR
Projekt

The role of beta-arrestin in achieving Wnt-signaling specificity (GC204/09/J030)

the molecular function and interacting proteins of beta-arrestin in different Wnt-pathways that beta-arrestin is required for Dishevelled (Dsh/Dvl) function in canonical and non-canonical Wnt-pathways...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 888 tis. Kč
    • •
  • 3 888 tis. Kč
    • •
  • GA ČR
Projekt

The Wnt signaling network – novel components and regulatory mechanisms (GA15-25100S)

The Wnt signaling pathway is a complex molecular network that regulates diverse processes during embryogenesis and in adult tissues. Dysfunction of Wnt signaling dedicated to elucidation of the Wnt pathway...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 7 350 tis. Kč
    • •
  • 7 350 tis. Kč
    • •
  • GA ČR
  • 1 - 10 z 1 603