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Projekt

Aspects of immune response and efficacy of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients (NU22-C-126)

1) Evaluate safety and imunogenicity of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients. 2) Evaluate association between booster dose of SARS-CoV-2 mRNA vaccine and risk of SARS-CoV-2 infect...

Transplantation

  • 2022 - 2023
  • 6 194 tis. Kč
  • 6 194 tis. Kč
  • MZ
Projekt

CMV specific mRNA vaccine for ex vivo stimulation of T cells in patiens after hematopoietic stem cell transplantation (NT13898)

Here, we propose to prepare mRNA vaccine against a number of candidate immunogenic CMV proteins. The vaccine will include antigen presenting cells electroporated mRNA coding for viral protective antigens and immuno...

FD - Onkologie a hematologie

  • 2012 - 2015
  • 9 717 tis. Kč
  • 9 717 tis. Kč
  • MZ
Projekt

Characterization of the ribosome translating pre-spliced mRNAs for the synthesis of antigenic peptide substrates for the MHC-I pathway (GA23-06884S)

that MHC-I APs are produced by a non-canonical mRNA translation event that is distinct data show that translation of pre-spliced mRNAs produces MHC-I AP substrates of mRNA translation, on the source of MHC-I peptides, and ...

Immunology

  • 2023 - 2025
  • 10 603 tis. Kč
  • 10 357 tis. Kč
  • GA ČR
Projekt

Development of an automated universal modular system for the production of biological mRNA vaccines and genetic medecines (EI24_063/0006705)

The project focuses on the development of a prototype of a modular automated universal system for the production of biological mRNA vaccines and genetic therapeutics. It builds upon the successful project “Innovation of Dual Conduct...

Analytical chemistry

  • 2025 - 2028
  • 44 972 tis. Kč
  • 0 tis. Kč
  • MPO
Projekt

Utilization of centrosomal proteins for prognostication and vaccinotherapy of chronic myeloid leukemia (NT13862)

) and development of DNA vaccines against this disease based on increased production of centrosomal proteins. Detection of HMMR/RHAMM, AURKA and ESPL1 mRNA level in blood cells of therapy. Development of DNA vaccines agains...

FD - Onkologie a hematologie

  • 2012 - 2015
  • 9 681 tis. Kč
  • 9 681 tis. Kč
  • MZ
Projekt

Monitoring the immune responses following SARS-CoV-2mRNA vaccination in patients with autoimmune neurological diseases (NU22-A-150)

after the 3rd dose of SARS-CoV-2 mRNA vaccine. 4. Validation of methods vaccination in comparison with unvaccinated patients according to the types of treatment of the incidence of vaccine side effects in ANDs, in...

Neurosciences (including psychophysiology)

  • 2022 - 2023
  • 4 086 tis. Kč
  • 4 086 tis. Kč
  • MZ
Projekt

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

The aim of this project is to find an optimal strategy of T cell stimulation using dendritic cells loaded with different myeloma antigens. Irradiated myeloma cells, myeloma mRNA or peptides derived from tumor associated proteins will be used...

FD - Onkologie a hematologie

  • 2006 - 2009
  • 6 929 tis. Kč
  • 6 587 tis. Kč
  • MZ
Projekt

Modern Times Without Us! Determinants and Effects of Technology Skepticism, Grisons 1900-1940 (GF23-09092L)

From the implementation of mechanical looms and threshing machines around 1800 to artificial intelligence (AI) and mRNA vaccines today, societies have always been skeptical about new and innovative technologies. However, little is k...

Applied Economics, Econometrics

  • 2023 - 2026
  • 4 949 tis. Kč
  • 4 949 tis. Kč
  • GA ČR
Projekt

Cystic Fibrosis (CF) - Ineraction between CF background and infection. (NR8458)

is about TLR expression on mRNA level - the key surface cell molecules which represent with possibility of vaccination treatment.......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2005 - 2009
  • 2 912 tis. Kč
  • 2 903 tis. Kč
  • MZ
Projekt

Parents' and lay public attitudes towards vaccination Evaluation and intervention to promote confidence in vaccinations (NU20-09-00454)

Vaccine hesitancy has been growing worldwide. The WHO has recently named vaccine hesitancy among top ten threats to public health. Maintaining public confidence in the safety and utility of vaccines is particularly challeng...

Public and environmental health

  • 2020 - 2023
  • 6 734 tis. Kč
  • 6 734 tis. Kč
  • MZ
  • 1 - 10 z 605