Filtry
Use of Monoclonal Anti-Idiotypic Antibodies for the Characterization af Tick-Borne Encephalitis Virus Receptor(s) on Vertebrate and Invertebrate Cells (GA508/93/2478)
GJ - Choroby a škůdci zvířat, veterinární medicina
- 1993 - 1995 •
- 127 tis. Kč •
- 254 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1993 - 1. 1. 1995
Uznané náklady
Podpora ze státního rozpočtu (200%)
Poskytovatel: Grantová agentura České republiky
Vaccination of small ruminants against tick-borne encephalitis virus (QJ1510104)
The goal of proposed project is development of experimental vaccine against tick-borne encephalitis (TBE) for veterinary use. The TBE vaccine for veterinary use especially for vaccination of small ruminants is not accessible so far will be d...
GF - Choroby, škůdci, plevely a ochrana rostlin
- 2015 - 2018 •
- 12 240 tis. Kč •
- 8 614 tis. Kč •
- MZe
Řešení projektu: 1. 4. 2015 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (70%)
Poskytovatel: Ministerstvo zemědělství
Delineating the mechanisms that regulate specific NMDA receptor subtypes in mammalian neurones (GA20-12420S)
N-methyl-D-aspartate receptors (NMDARs) are a subclass of glutamate receptors ischaemia and Alzheimer’s disease. NMDARs are tetrameric protein complexes composed. However, the roles played by specific NMDAR subtypes in phys...
Pharmacology and pharmacy
- 2020 - 2023 •
- 12 389 tis. Kč •
- 12 296 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 30. 6. 2023
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Regulation of trafficking and function of the GluN3A-containing NMDA receptors in the mammalian neurons (GA18-04329S)
N-methyl-D-aspartate receptors (NMDARs) play critical roles in excitatory neurotransmission and excitotoxicity in mammalian neurones. Both the number and type of NMDARs their early processing, surface stability and degradation. The ...
Neurosciences (including psychophysiology)
- 2018 - 2020 •
- 6 821 tis. Kč •
- 6 593 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2020
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Grantová agentura České republiky
Immunomodulatory effects of tick saliva and its impact on the transmission of tick-borne encephalitis virus and Borrelia burgdorferi (GA524/96/0142)
Tick saliva contains a variety of pharmacologically active facilitating blood feeding on a host. In addition to anti-haemostatic and vasodilatory effects they possess pronounced anti-inflammatory and immunosuppressive activities-bor...
EH - Ekologie – společenstva
- 1996 - 1998 •
- 1 828 tis. Kč •
- 1 048 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1996 - 1. 1. 1998
Uznané náklady
Podpora ze státního rozpočtu (57%)
Poskytovatel: Grantová agentura České republiky
Biological activity and pharmacokinetic properties of 3?C substituted derivatives of pregnanolone (NS10365)
(NMDAR) antagonists. Nonetheless, their therapeutic potential is rather limited due to high coincidence of negative side effects. Regarding the fact, that NMDAR are very of NMDAR offers a possibility to search for drugs se...
FR - Farmakologie a lékárnická chemie
- 2009 - 2011 •
- 4 931 tis. Kč •
- 4 834 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Ministerstvo zdravotnictví
Trihetromeric NMDA receptors - physiological and pathophysiological functional properties (LTAUSA19122)
The aim of the project is to obtain more detailed information about the functional properties of NMDAR and their changes caused by the presence of genetic unexplored mutations on NMDAR physiology, the evaluation of the significance ...
Neurosciences (including psychophysiology)
- 2020 - 2022 •
- 5 396 tis. Kč •
- 5 396 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Novel functions of viral and cellular proteins in Tick-borne encephalitis virus infection (GA15-03044S)
Project aims to better characterize the replication of the tick-borne encephalitis virus, one of the epidemiologically most important tick-borne pathogens in the Europe and Czech Republic. Three up-till now neglected processes will be studie...
EE - Mikrobiologie, virologie
- 2015 - 2017 •
- 6 850 tis. Kč •
- 6 775 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2015 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Synaptic Effects and Neuroprotective Properties of NMDA Receptor-Modulating Neurosteroids (GJ16-03913Y)
. On the other hand, excessive tonic NMDAR activation mediates excitotoxicity. This paradoxical involvement of NMDARs in both neuroprotection and neurotoxicity motivates an interest in pharmacological agents selectively blocking p...
ED - Fyziologie
- 2016 - 2020 •
- 4 509 tis. Kč •
- 4 509 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 11. 12. 2020
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Novel open-channel blockers of NMDA receptors with enhanced membrane-to-channel inhibition (GA24-10026S)
N-methyl-D-aspartate receptors (NMDARs) are essential for developing many central nervous system diseases. Although approved blockers acting at NMDARs potent blockers of GluN1/GluN2 NMDARs based on the structure of K2060 th...
Medicinal chemistry
- 2024 - 2026 •
- 12 027 tis. Kč •
- 12 027 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2024 - 31. 12. 2026
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
- 1 - 10 z 850