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Projekt

Mucosal tolerance in models of orthotopic corneal transplantation studies of the mechanisms and clinical potential (GA310/99/0360)

Immunosuppression induced by antigen administrated through mucosal surfaces mechanisms of mucosal tolerance in transplantation system and designing new therapeutic the study of the phenotype and function of cells presenting antigen ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 1 858 tis. Kč
    • •
  • 1 308 tis. Kč
    • •
  • GA ČR
Projekt

Vaccines for induction of mucosal and systemic immunity (IBS5020311)

oral vaccines for mucosal immunization against selected human and veterinary the possibility of delivering ACT directly to mucosal surfaces by the means of a live E. coli fusions to the mucosal immune system and the induct...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 6 070 tis. Kč
    • •
  • 5 365 tis. Kč
    • •
  • AV ČR
Projekt

Environmental factors, mucosal immunity and regulatory T cells in pathogenesis and prevention of type 1 diabetes (T1D) (IAA5020405)

gut mucosalimmunity in genetically-susceptible individuals. Mucosal surfaces represent the major interface with the outer environment. The development of gut mucosal and gut microflora on the development of protective mucosal

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2007
    • •
  • 2 581 tis. Kč
    • •
  • 2 181 tis. Kč
    • •
  • AV ČR
Projekt

Evolution of mucosal antimicrobial immunity (GA206/07/0378)

Mucosal surfaces represent important entrance gateway for infection and it is supposed that majority of pathogenic microorganisms enter the body through mucosae is focused on the study of mucosal defense mechanisms in the model olig...

EG - Zoologie

  • 2007 - 2011
    • •
  • 5 427 tis. Kč
    • •
  • 5 427 tis. Kč
    • •
  • GA ČR
Projekt

Strategy of oral immunization significance for systemic and mucosal immunity and use for prevention and therapy (VS96149)

Possibilities of modulation of mucosal and systemic immunity after oral immunization will be studied. The effect of various adjuvants, carriers and vectors on induction of protective immunity or oral tolerance will be tested. Bacillus firmus...

EA - Morfologické obory a cytologie

  • 1996 - 2000
    • •
  • 16 931 tis. Kč
    • •
  • 14 895 tis. Kč
    • •
  • MŠMT
Projekt

Mucosal tolerance in a murine model of corneal transplantation (ME 300)

Study of cellular and molecular mechanisms of rejection and tolerance of orthotopic corneal allografts in the experimental murine model. Study of potencial of the mucosal tolerance as a strategy for suppression of the immunological rejection...

EC - Imunologie

  • 1998 - 2000
    • •
  • 2 631 tis. Kč
    • •
  • 935 tis. Kč
    • •
  • MŠMT
Projekt

Intranasal vaccination in prevention of autoimmune diseases (NS10340)

Mechanisms of induction of mucosal protective immunity by intranasal administration of autoantigens using bioptic material of human nasal mucosa and mouse models of type 1. diabetes and ulcerative colitis. Role of NALT (Nasal associated lymp...

EC - Imunologie

  • 2009 - 2011
    • •
  • 2 561 tis. Kč
    • •
  • 2 561 tis. Kč
    • •
  • MZ
Projekt

Methods of eradication of production diseases of cattle - bovine viral diarrhoea - mucosal disease and paratuberculosis (QI101A094)

The aim of the project is to introduce methods of eradication of two economicaly important diseases of cattle - bovine viral diarrhoea - mucosal disease and paratuberculosis. During solution of the project, vaccine against BVD-MD will be dev...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2010 - 2014
    • •
  • 16 926 tis. Kč
    • •
  • 15 134 tis. Kč
    • •
  • MZe
Projekt

Systemic and mucosal immune response after adjuvant mucosal immunization with inactivated influenza virus (GA310/02/0467)

Efficient mucosal immunization should be optimal for protection against influenza. The use of live vaccines is too risky in human. There is a search for potent and safe adjuvants to increase the immunogenicity of inactivated virus. Strong ad...

EC - Imunologie

  • 2002 - 2004
    • •
  • 2 907 tis. Kč
    • •
  • 2 907 tis. Kč
    • •
  • GA ČR
Projekt

Inflammatory bowel disease From immunopathogenetic mechanisms to the development of potencial vaccine (IAA5020205)

of immunoregulatory functions and impairment of the mucosal immune response to normal bacterial murine models of human disease, 3) to manipulate the mucosal immune responses by mucosal administration of bacterial antigens ...

EC - Imunologie

  • 2002 - 2006
    • •
  • 6 168 tis. Kč
    • •
  • 4 688 tis. Kč
    • •
  • AV ČR
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