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2 739 (0,095s) •

Projekt

Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors (GA301/08/1649)

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic events cause universal overactivity of the cell cycle cdks in human cancers, ant their inhibition...

FD - Onkologie a hematologie

  • 2008 - 2012
    • •
  • 6 985 tis. Kč
    • •
  • 6 985 tis. Kč
    • •
  • GA ČR
Projekt

Mutual relationship between cytoskeletal structures and activity of cyclin dependent kinases and their role in regulation of the cell cycle of algae (GA204/97/0576)

The main goal is to study specific interactions between cytoskeletal proteins and the cell cycle control protein (cyclins, cyclin dependent kinases etc.). This research will involve the immunolocalization of the ce...

EA - Morfologické obory a cytologie

  • 1997 - 1999
    • •
  • 2 397 tis. Kč
    • •
  • 1 811 tis. Kč
    • •
  • GA ČR
Projekt

Chemical genetic analysis of role of cyclin-dependent kinases in cancer cell lines (GJ15-17282Y)

Cyclin-dependent kinases (CDKs) are universal eukaryotic protein regulators that promote cell cycle, initiation of DNA replication, and mitosis. Why CDKs/cyclins cannot compensate for an absence of CDK1-cyclin<...

CE - Biochemie

  • 2015 - 2017
    • •
  • 3 665 tis. Kč
    • •
  • 3 665 tis. Kč
    • •
  • GA ČR
Projekt

The mechanism of inhibitory action imposed on cyclin-dependenz kinases in malignant human B lymphocytes (GA304/01/0564)

The activity of cyclin-dependent kinases and its transport into the nucleus is necessary for the transition through Gl phase and for the progression of S phase. Our primary goal is to study the mechanism of TGFbetal cytosta...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 156 tis. Kč
    • •
  • 4 156 tis. Kč
    • •
  • GA ČR
Projekt

Inhibitors of cyclin-dependent kinases (cdc 2, cdk 2) derived from olomoucine (GA301/96/0437)

CE - Biochemie

  • 1996 - 1996
    • •
  • 0 tis. Kč
    • •
  • 1 956 tis. Kč
    • •
  • GA ČR
Projekt

Regulation of mitosis by plant specific cyclin-dependent kinase B in green alga Chlamydomonas reinhardtii (GA204/06/0102)

Regulation of mitosis is one of the most studied, however, still not completely characterized processes. In plants a specific cyclin-dependent kinase, CDKB, is thought to be involved. CDKB is a plant specific kinase

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 3 266 tis. Kč
    • •
  • 3 266 tis. Kč
    • •
  • GA ČR
Projekt

The changes in the activity of cyclin dependent kinases and in phophorylation of their target proteins during the algal cell cycle under presence of.. (IAC5020012)

up to now. Complexes of cyclin dependent kinases (CDK) and cyclins are the key phases is dependent on the activity of these complexes. Not only substrates of CDK-cyclin complexes like cytoskeleta...

EA - Morfologické obory a cytologie

  • 2000 - 2000
    • •
  • 229 tis. Kč
    • •
  • 149 tis. Kč
    • •
  • AV ČR
Projekt

Targeted Transport of Purine Cyclin-dependent Kinase Inhibitors into Cancer Cells (GA15-15264S)

The project is focused on the synthesis and study of biological effects of some new conjugates of cyclin-dependent kinase inhibitors, derived from cytokinins, which have shown significant anticancer effect, with selected po...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
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  • 4 631 tis. Kč
    • •
  • 4 631 tis. Kč
    • •
  • GA ČR
Projekt

Characterization of a novel function for cyclin-dependent kinase 12 (Cdk12) (GA17-13692S)

Cyclin-dependent kinase 12 (Cdk12) is a transcriptional Cdk that was found (HGSOC), one of the most lethal cancers. The mutations compromised the kinase genes including BRCA1, identifying this kinase as a ...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 9 405 tis. Kč
    • •
  • 9 405 tis. Kč
    • •
  • GA ČR
Projekt

The effect of cyclin dependent kinase on chloroplast division in green algae of genera Chlamydomonas and Scenedesmus (KJB5020305)

We will follow time and functional relations ofchloroplast division on the activity of cyclin-dependent kinases (CDK) during cell cycle of algae dividing by multiple fission. For experiments, well established system of sync...

EA - Morfologické obory a cytologie

  • 2003 - 2005
    • •
  • 2 408 tis. Kč
    • •
  • 2 060 tis. Kč
    • •
  • AV ČR
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