Filtry
The role of mitochondria in toxic liver injury and in liver regeneration (GP305/09/P145)
for hepatotoxic drugs and play very important role in reparative processes. The aim of this study is to describe the effect of toxic liver injury induced by model hepatotoxins to treatment of toxic liver ...
ED - Fyziologie
- 2009 - 2011 •
- 1 446 tis. Kč •
- 1 446 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Advanced physical methods in hepatotoxicity studies (LTC19040)
with drug-related liver problems (DILI). Our expertise will provide this project of PRO-EURO-DILI-NET COST is to create a translational pathway through agents (such as drugs).......
Biophysics
- 2019 - 2022 •
- 7 598 tis. Kč •
- 7 598 tis. Kč •
- MŠMT
Řešení projektu: 15. 5. 2019 - 15. 10. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Generation of hepatocyte-derived cellular models for preclinical testing of drugs (GAP304/10/0149)
Primary human hepatocytes are recommended in guidelines of many national drug authorities (such as FDA) in the different stages of drug development. Limited in biotransformation enzymes activities and in magnitude of induction, and ...
FR - Farmakologie a lékárnická chemie
- 2010 - 2012 •
- 4 499 tis. Kč •
- 4 499 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2010 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Can Statins Attenuate a development of cholestatic liver disease? (NS9739)
Extrahepatic cholestasis will be induced by the method of common bile duct ligation. The potential effect of fluvastatin attenuating the development of cholestatic liver injury will be evaluated by the mesurements of the ma...
FJ - Chirurgie včetně transplantologie
- 2008 - 2010 •
- 2 273 tis. Kč •
- 2 273 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Critical assessment of some current natural products with potential therapeutic applications in liver injuries in vivo and in vitro evaluation (NR9379)
- Hepatocyte injury and death is a prominent feature in all liver disease (in vitro) will be adopted to study the liver injury produced by different insults will be used, for investigations of the protective effect...
FR - Farmakologie a lékárnická chemie
- 2007 - 2009 •
- 2 843 tis. Kč •
- 2 787 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Ministerstvo zdravotnictví
Is the liver affected by non-alcoholic liver disease (NAFLD) more sensitive to toxic injury? (GP305/08/P184)
injury. There are reports of mitochondrial dysfunction, liver steatosis, increased by NAFLD. All these conditions increase sensitivity of the liver to acute toxic injury sensitivity or furthermore they even discov...
ED - Fyziologie
- 2008 - 2010 •
- 1 419 tis. Kč •
- 1 419 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
New treatment techniques of liver injury in field conditions (MO03021100001)
Experimentally verify the security and effectiveness of a new operating technique of livers. To master practically the technique in the conditions of a clinic at planned liver resections.......
FI - Traumatologie a ortopedie
- 2000 - 2002 •
- 367 tis. Kč •
- 367 tis. Kč •
- MO
Řešení projektu: 1. 1. 2000 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo obrany
The risk factors of the liver and bile ducts injury in the preoperative period of the donor (ND6607)
In the preoperative period, there are a number of risk factors which may cause infury to donor organs. The aim to establish - using bile analysis and bile duct histochemistry - the impact of these factors on the quality of the liver and bile...
FJ - Chirurgie včetně transplantologie
- 2001 - 2003 •
- 1 630 tis. Kč •
- 1 564 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (96%)
Poskytovatel: Ministerstvo zdravotnictví
31P MR spectroscopy for the non-invasive determination of the degree of chronic liver injury. (NB6630)
of liver injury. In a number of patients, an invasive examination procedure an important role in energy metabilism of the liver. There is a correlation between the degree of liver injury and changes in ph...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2001 - 2003 •
- 1 385 tis. Kč •
- 1 267 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (91%)
Poskytovatel: Ministerstvo zdravotnictví
Primary cultures of human hepatocytes as a model for toxicological, pharmacological and biochemical studies in transplantation medicine. (NT13591)
liver tissue obtained from multiorgan donors, for whom suitable recipient is not available. Primary cultures will be used for the study of liver-specific transcriptional between drugs especially in the context of immunosup...
FJ - Chirurgie včetně transplantologie
- 2012 - 2015 •
- 6 162 tis. Kč •
- 6 162 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
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