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3 172 (0,095s)

Projekt

Pattern of DNA methylation in retroviral regulatory sequences (GA204/01/0632)

CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the methylatio...

EB - Genetika a molekulární biologie

  • 2001 - 2003
  • 4 657 tis. Kč
  • 2 210 tis. Kč
  • GA ČR
Projekt

Involvement of nuclear Vinculin in ubiquitin relay of proteasomes during early meiotic events. (GA18-19714S)

in mammalian meiosis remain poorly characterized. Our preliminary data have shown that protein Vinculin (VCL) may be involved in UPS regulation. Our preliminary experiments-proteasome system (UPS) is a key regulators

Cell biology

  • 2018 - 2022
  • 9 515 tis. Kč
  • 8 543 tis. Kč
  • GA ČR
Projekt

Research and development of automatized precise flat polishing of surfaces made from very hard and brittle materials, project and construction of a prototype. (FF-P2/047)

Solving of the automation of precise plane polishing of sealing and regulation plates of HIGH-TECH oxide ceramics. The principle of the applied pressure polishing of these parts using the diamond suspension should be completed with a pre...

JH - Keramika, žáruvzdorné materiály a skla

  • 2003 - 2005
  • 6 508 tis. Kč
  • 2 187 tis. Kč
  • MPO
Projekt

Alternative splicing as a regulator of auxin transport (GA16-26428S)

morphogenesis and regulation of hormonal pathways. On the example of family of important hormonal regulators, we will demonstrate function alternative splicing as integrator of root development and hormonal response. Our prelim...

EB - Genetika a molekulární biologie

  • 2016 - 2020
  • 5 711 tis. Kč
  • 5 711 tis. Kč
  • GA ČR
Projekt

The role of MDM2 in epithelial-to-mesenchymal transition implication for cancer progression (GPP301/12/P407)

dissemination of tumor cells. Recent studies are suggesting a role of MDM2 in the regulation cells, the aim of this project is to elaborate on our original preliminary data and analyze the causes and consequences of the EMT-associa...

FD - Onkologie a hematologie

  • 2012 - 2016
  • 1 963 tis. Kč
  • 1 963 tis. Kč
  • GA ČR
Projekt

Mechanisms and Effects of Inverse TAp63 and ΔNp63 Regulation (GA23-05951S)

expression patterns in normal tissues and in human cancers. From preliminary data showing epigenetic regulation of TAp63 and ΔNp63, including isoform switching after DNA factors to regulate induction/repression of TAp63/ΔN...

Biochemistry and molecular biology

  • 2023 - 2025
  • 9 589 tis. Kč
  • 9 418 tis. Kč
  • GA ČR
Projekt

Regulation of phospholipase D alpha 1 function by MPK3-dependent phosphorylation (GA16-22044S)

processes including cytoskeleton regulation. Based on our preliminary results, PLDa1 is to functionally characterize PLDa1 with respect to its regulation by MPK3-dependent......

EB - Genetika a molekulární biologie

  • 2016 - 2018
  • 5 973 tis. Kč
  • 5 961 tis. Kč
  • GA ČR
Projekt

Activity of inflammatory regulator NF-kappaB modulated by alteration of arachidonic acid metabolism (GP524/06/P345)

Inflammation is an inevitable component of both innate immunity and host defense system. NF-kappaB as a ubiquitous transcriptional factor and a pleiotropic regulator of many genes represents an essential regulator of inflammatory re...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2006 - 2008
  • 870 tis. Kč
  • 870 tis. Kč
  • GA ČR
Projekt

The interactions between cytokinins and abscisic in stomatal regulation of gas exchange (GA522/02/1099)

Shortage of water in still increasing extent restricts plant production all over the world, and an efficient regulation of gas exchange is a prerequisite factors participating in root-to-shoot communication and in the regulation of ...

ED - Fyziologie

  • 2002 - 2004
  • 6 225 tis. Kč
  • 2 039 tis. Kč
  • GA ČR
Projekt

Unravelling the regulation and interactions of p63. (GA19-06530S)

, but, unlike p53, how p63 is regulated at transcriptional/post-transcriptional levels will address these gaps in basic knowledge. Based on preliminary data, we will study the regulation of p63 protein and mRNA levels and s...

Cell biology

  • 2019 - 2023
  • 8 388 tis. Kč
  • 7 809 tis. Kč
  • GA ČR
  • 1 - 10 z 3 172