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Projekt

Metabolic reprogramming of mesenchymal stromal cells for regenerative medicine applications (GA22-31457S)

Regenerative properties of multipotent mesenchymal stromal cells (MSC of characterizing the MSC metabolic profile to improve their regenerative abilities. As model conditions, we will use MSC primed with inflammatory cytoki...

Cell biology

  • 2022 - 2025
  • 10 127 tis. Kč
  • 10 127 tis. Kč
  • GA ČR
Projekt

Intrathecal and intramuscular application of mesenchymal stem cells and their secretome in the treatment of amyotrophic lateral sclerosis (GA15-06958S)

application of human mesechymal stromal cells (MSCs) and MSCs-conditioned medium (CM. Treatment yeilding better results will be combined with MSC intramuscular application into hindlimb muscles to prevent dying-back axonal...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2019
  • 7 413 tis. Kč
  • 7 413 tis. Kč
  • GA ČR
Projekt

Utilisation of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization. (7E09031)

stem cells (MSCs). There are no standards for characterisation, isolation or identification of MSCs from any tissue, nor are there standard protocols for differentiation of MSCs to various lineages. Additionally, surface m...

EA - Morfologické obory a cytologie

  • 2009 - 2011
  • 2 659 tis. Kč
  • 2 659 tis. Kč
  • MŠMT
Projekt

Metabolic reprogramming of mesenchymal stromal cells for regenerative medicine applications (GA21-19519S)

profile of multipotent mesenchymal stromal cells (MSC) to improve their regenerative synthesis. We will study effects of MSC cytokine priming and spheroid formation on metabolic reconfiguration of MSC towards aerobic glyco...

Cell biology

  • 2021 - 2023
  • 11 148 tis. Kč
  • 11 148 tis. Kč
  • GA ČR
Projekt

The use of the stem cells in growth plate injury treatment in pigs- experimantal study (NR9296)

The subject of study is to evaluate using of autologous and allogenic MSCs in growth cartilage defect prevention or therapy in minipigs....

FI - Traumatologie a ortopedie

  • 2007 - 2008
  • 1 960 tis. Kč
  • 1 900 tis. Kč
  • MZ
Projekt

Safety and efficacy evaluation of allogeneic mesenchymal stem cells derived from umbilical cord tissue in repair of cartilage defects preclinical study on animal model. (NV19-06-00355)

, autologous mesenchymal stem cells (MSCs) are being used clinically to improve cartilage method of collection and reduced functionality in elderly patients. MSCs derived from safety and efficacy of transplantation of allogeneic por...

Biomaterials (as related to medical implants, devices, sensors)

  • 2019 - 2022
  • 14 363 tis. Kč
  • 14 363 tis. Kč
  • MZ
Projekt

Transport of inorganic phosphate across the placente of the rat (GA305/96/1722)

FR - Farmakologie a lékárnická chemie

  • 1996 - 1996
  • 0 tis. Kč
  • 0 tis. Kč
  • GA ČR
Projekt

Therapeutic potential of mesenchymal stem cells in experimental porcine sepsis. (NV15-32801A)

, mesenchymal stem cells (MSC, also bone marrow stromal cells) emerged as such possible therapeutic option. Several studies have demonstrated the beneficial effects of MSC effects of MSC will be tested in the porcine model ...

FP - Ostatní lékařské obory

  • 2015 - 2018
  • 4 865 tis. Kč
  • 4 865 tis. Kč
  • MZ
Projekt

Paracrine effect of mesenchymal stem cell-secretome and its modification for the treatment of spinal cord injury (GA17-03765S)

(MSCs) beneficial effects in neural repair. MSCs produce a range of cytokines and neurotrophic effects, while MSC-secretome or conditioned media (CM) may cause tissue repair and characterize the secretion profiles of M...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2019
  • 5 238 tis. Kč
  • 4 851 tis. Kč
  • GA ČR
Projekt

The principals and mechanisms of the early genesis of dental primordia of eutherian homodont and heterodont dentition (IAA6045606)

On a set of embryos and foetuses of placental mammals from various taxonomical groups (Insectivora, Rodentia, Artiodactyla, Cetacea), mechanisms and principles of dental primordia for multicusped teeth of placental mammals, several ...

EG - Zoologie

  • 1996 - 1998
  • 2 066 tis. Kč
  • 932 tis. Kč
  • AV ČR
  • 1 - 10 z 88