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Filtry

93 494 (0,168s)

Výsledek výzkumu

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

, the sensitizing effects of rapamycin and dexamethasone. In yeast, glucose activates protein that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensitize ...

Biochemistry and molecular biology

  • 2017
  • Jimp
  • Odkaz
Výsledek výzkumu

Therapeutic Activity and Biodistribution of a Nano-Sized Polymer-Dexamethasone Conjugate Intended for the Targeted Treatment of Rheumatoid Arthritis

homogenates. The dexamethasone conjugate exhibited a dose-dependent healing effect on arthritis and an improved therapeutic outcome compared to free dexamethasone. Overall effects of glucocorticoid dexamethasone c...

Polymer science

  • 2023
  • Jost
Výsledek výzkumu

HPMA copolymer conjugates for dual therapy

) and dexamethasone (Dex), both bound to the same polymer or combination of differently attached Dox, via pH-sensitive hydrazone linkage or tetrapeptide spacer (GFLG)....

CD - Makromolekulární chemie

  • 2008
  • D
Výsledek výzkumu

Dexamethasone suppression test in first-episode schizophrenia

Rates of DST nonsuppression in schizophrenia including first-episode schizophrenia are influenced by the stage of illness and medication status. The impairment of feedback regulation of cortisol secretion may be related to different biopathogenetic m...

FL - Psychiatrie, sexuologie

  • 2006
  • Jx
Výsledek výzkumu

Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line

). We examined whether glucocorticoid dexamethasone influences AHR-mediated induction of CYP1A1 enzyme in the JEG-3 cell line. We found that dexamethasone dose- and time-dependently suppresses CYP1A1 transactivation in gene...

FR - Farmakologie a lékárnická chemie

  • 2013
  • Jx
  • Odkaz
Výsledek výzkumu

NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess

glucocorticoid dexamethasone in the cardiovascular system in vitro and in vivo in mice for the essential NADPH oxidase subunit p22phox. We show that dexamethasone induced NADPH oxidase-dependent ROS generation, leading to ...

Biochemistry and molecular biology

  • 2020
  • Jimp
  • Odkaz
Výsledek výzkumu

MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN TRANSPLANT ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA ENROLLED IN THE EMN02/HO95 PHASE 3 TRIAL

MRD detection is a sensitive tool to measure response in MM. We assessed MRD by MFC in newly diagnosed MM patients (pts) enrolled in the EMN02/HO95 phase 3 trial. Pts were ≤65 years old and received Bortezomib-Cyclophosphamide-Dexametha...

Hematology

  • 2017
  • D
Výsledek výzkumu

MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN TRANSPLANT ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: RESULTS FROM THE EMN02/HO95 PHASE 3 TRIAL

MRD detection is a sensitive tool to measure response in MM. We assessed MRD by MFC in newly diagnosed MM patients (pts) enrolled in the EMN02/HO95 phase 3 trial. Pts were ≤65 years old and received Bortezomib-Cyclophosphamide-Dexametha...

Hematology

  • 2017
  • D
Výsledek výzkumu

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study

Background Bortezomib with dexamethasone is a standard treatment option for relapsed or refractory multiple myeloma. Carfilzomib with dexamethasone has shown was to compare thecombination of carfilzomib and dexamethasone wi...

FD - Onkologie a hematologie

  • 2015
  • Jx
  • Odkaz
Výsledek výzkumu

Health-Related Quality-of-Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone

To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus...

Oncology

  • 2016
  • Jimp
  • Odkaz
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