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1 297 (0,134s) •

Projekt

PURINE DE NOVO SYNTHESIS DEFECTS - METABOLIC STUDY (NR7796)

Purine bodies are synthesized de novo in ten step enzymatic pathway. Only two hamster cells and Saccharomyces cerevisiae strains - aberrant in purine de novo of our work are to develop methods capable to follow hum...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
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  • 1 419 tis. Kč
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  • 1 412 tis. Kč
    • •
  • MZ
Projekt

Deactivation of fly ash as a catalyst in de novo synthetci reactions producing persistent organic pollutants (POP) (IAA4072206)

On the basis of the knowledge of the dehalogenation and de novo synthetic reactions occurring in the gaseous phase at the fly ash microparticles, to search at temperatures lower than those rewuired for the de novo ...

CI - Průmyslová chemie a chemické inženýrství

  • 2002 - 2004
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  • 3 085 tis. Kč
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  • 1 330 tis. Kč
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  • AV ČR
Projekt

Metabolic switch in liver regeneration (GA23-04671S)

RRegeneration of liver epitomizes very fast proliferating tissue. This process requires de novo synthesis of nucleotides and efficient synthesis of amino acids. We will study metabolic switch needed for liver regeneration after part...

Cell biology

  • 2023 - 2025
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  • 12 579 tis. Kč
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  • 12 141 tis. Kč
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  • GA ČR
Projekt

De novo design of synthetically feasible and biologically active compounds guided by artificial intelligence (LUAUS23262)

The overall goal of the project is development of approaches to de novo design and structure optimization, their benchmarking and prospective validation. The particular goals are: i) high synthetic accessibility of generated molecul...

Physical chemistry

  • 2023 - 2026
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  • 11 818 tis. Kč
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  • 11 818 tis. Kč
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  • MŠMT
Projekt

Detection of de novo methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. (IZ3720)

FD - Onkologie a hematologie

  • 1996 - 1998
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  • 684 tis. Kč
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  • 684 tis. Kč
    • •
  • MZ
Projekt

Prevalence studies of de novo purine synthesis disorders in patients with neurological impairment (NV15-28979A)

Many patients are examined in the Institute of Inherited Metabolic Disorders with a diagnostic efficiency of approximately 2%. High numbers of them suffer with neurological symptoms that do not fit into any currently known metabolic disorder. Therefo...

CE - Biochemie

  • 2015 - 2018
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  • 3 269 tis. Kč
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  • 3 269 tis. Kč
    • •
  • MZ
Projekt

The Role of De Novo Lipogenesis in Regulation of Insulin Sensitivity in adipose tissue in obese (NV19-01-00263)

Disturbances of de novo lipogenesis (DNL) are one of the features of dysfunction of adipose tissue (AT). Disturbances of DNL play a role in development of metabolic complications of obesity. The goal of this project is to investigat...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2023
    • •
  • 13 162 tis. Kč
    • •
  • 12 629 tis. Kč
    • •
  • MZ
Projekt

New screening system of genetic defects of the de novo purines synthesis and its application in differential diagnosis of patients with psychomotor retardation of unknown etiology (LH11031)

1)Preparation of the commercionally unavailable, isotopicaly labeled and non-labeled intermediates of the de novo purine synthesis (DNPS) in the ammount and purity allowing the calibration of the choosen detection methods. 2)Impleme...

EB - Genetika a molekulární biologie

  • 2011 - 2013
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  • 2 954 tis. Kč
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  • 2 954 tis. Kč
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  • MŠMT
Projekt

Ketogenic diet as a modulator of de novo lipogenesis in liver and visceral adipose tissue amount KETOLIVA (NU20J-01-00005)

de novo lipogenesis in relation to metabolic signature in obese women...

Endocrinology and metabolism (including diabetes, hormones)

  • 2020 - 2024
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  • 7 836 tis. Kč
    • •
  • 7 499 tis. Kč
    • •
  • MZ
Projekt

The importance of being mitofit targeting mitochondrial metabolism in glioblastoma (GF24-10406K)

in order to drive de novo nucleotide synthesis in order to proliferate. We will study changes in mitochondrial metabolism, respiration and de novo nucleotide synthesis......

Cell biology

  • 2024 - 2026
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  • 7 312 tis. Kč
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  • 7 312 tis. Kč
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  • GA ČR
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