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Filtry

3 389 (0,088s)

Výsledek výzkumu

Favorable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer

of membranous β-catenin and cytoplasmic β-catenin expression in pancreatic cancer patients adenocarcinoma were retrospectively studied. The membranous β-catenin, cytoplasmic

Oncology

  • 2023
  • Jimp
  • Odkaz
Výsledek výzkumu

Negative prognostic significance of primary cilia and cytoplasmatic beta-catenin expression in non-small cell lung cancer.

cytoplasmic β-catenin expression (25-75%) than with lower cytoplasmic β-catenin expression-catenin expression in NSCLC and a negative prognostic significance of cytoplasmic ...

Oncology

  • 2024
  • Jost
  • Odkaz
Výsledek výzkumu

Negative prognostic significance of primary cilia and cytoplasmic β-catenin expression in non-small cell lung cancer

cytoplasmic β-catenin expression (25–75%) than with lower cytoplasmic β-catenin expression cytoplasmic β-catenin (25–75%) (p=0.009). Multivariate testing of the whole g...

Oncology

  • 2024
  • Jimp
  • Odkaz
Výsledek výzkumu

Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients

%) or cytoplasmic β-catenin expression (≤75%) than in patients with higher expressions), cytoplasmic β-catenin (P=0.005), pVHL (P=0.042), PD-L1 (P=0.049) and PD-1 (P=0.028 and combined prognostic ...

Oncology

  • 2024
  • Jimp
  • Odkaz
Výsledek výzkumu

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling

formation and function is regulated. Recent work has implicated WNT/β-catenin signaling suggests that WNT/β-catenin signaling negatively regulates cilia formation, possibly of WNT/β-catenin signa...

Biochemistry and molecular biology

  • 2021
  • Jimp
  • Odkaz
Výsledek výzkumu

Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway

-catenin pathway, which promotes the degradation of β-catenin via its phosphorylation, but not CK1α-like, resulted in a strong activation of the Wnt/β-catenin pathway. Wnt-3a, a CK1α-dependent and Wnt-depe...

Cell biology

  • 2024
  • Jimp
  • Odkaz
Výsledek výzkumu

WNT/β-Catenin Signaling in Vertebrate Eye Development

and extracellular signaling pathways including WNT/β-catenin signaling. This signaling pathway, the activity of WNT/β-catenin signaling is tightly controlled. Faulty regulation of WNT/β recent findings on...

EB - Genetika a molekulární biologie

  • 2016
  • Jx
  • Odkaz
Výsledek výzkumu

Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma

We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role, they are different entities based on immunohistochemical and molecular analysis of beta-...

FP - Ostatní lékařské obory

  • 2007
  • Jx
Výsledek výzkumu

Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups

and indirect immunofluorescence were employed for the detection of β-catenin, filamin for β-catenin and filamin A, as well as weak positivity for GAB1. The same, these groups are thought to be distinguishable usin...

Oncology

  • 2017
  • Jimp
  • Odkaz
Výsledek výzkumu

β-catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation

The canonical Wnt signaling pathway is mediated by interaction of b-catenin mainly investigated by rather unspecific genetic manipulations of b-catenin specifically abrogates b-catenin-TCF/LEF interaction. Disruption of the...

Hematology

  • 2020
  • Jimp
  • Odkaz
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