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1 927 (0,081s) •

Projekt

Non Covalent DNA Recognition Strategies for Design and Synthesis of New Metallodrugs (OC D20.004)

Non Covalent DNA Recognition Strategies for Design and Synthesis of New Metallodrugs...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 2 190 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • MŠMT
Projekt

Non-covalent DNA recognition strategies for design and synthesis of new metallo-drugs (1P05OC072)

procural of specific and easily modifiable structures for location of group capable of noncovalent bond to DNA...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Projekt

Analysis of the interactions of mutagens, carcinogens and anti-cancer drugs with biopolymers by means of electrochemical and biochemical methods. (IAA4004901)

with proteins (including DNA covalent adduct-specific antibodies, enzymes and protein p53 with mercury abd solid electrodes in studies of covalent and/or non-covalent interactions carcinogens, mutagens or anti-can...

CE - Biochemie

  • 1999 - 2001
    • •
  • 2 422 tis. Kč
    • •
  • 827 tis. Kč
    • •
  • AV ČR
Projekt

Platinum Metal Complexes as DNA-Protein Cross-Linking Agents (ME08017)

This project is aimed to find out data on covalent interactions of DNA modified by platinum complexes with proteins....

BO - Biofyzika

  • 2008 - 2010
    • •
  • 2 226 tis. Kč
    • •
  • 2 226 tis. Kč
    • •
  • MŠMT
Projekt

Examination of safety of the alkaloids from Macleaya cordata by study their interactions with DNA using modern analytical tools (GPP503/11/P312)

-covalent interactions and covalent binding of the alkaloids with native chromosomal DNA, synthetic oligonucleotides and different alternative structures of DNA. In final part......

GM - Potravinářství

  • 2011 - 2013
    • •
  • 1 992 tis. Kč
    • •
  • 1 992 tis. Kč
    • •
  • GA ČR
Projekt

Development of nanoparticle-based cytostatics and enzymes for enhanced chemotherapy of human neuroblastomas and study of mechanisms of their action (GA14-18344S)

to covalently modify DNA (cytochromes P450, cytochrome b5, peroxidases). Comparison such as intercalative and DNA covalent-binding abilities will also be examined. Such a studyThe aim is to prepare encapsulated

CE - Biochemie

  • 2014 - 2016
    • •
  • 9 130 tis. Kč
    • •
  • 9 103 tis. Kč
    • •
  • GA ČR
Projekt

Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)

protein p53 and its binding to DNA. Better understanding of this key protein binding to DNA and particularly to supercoiled DNA, (ii) the effect ofthe DNA-specific binding of p53 to different concensus sequences w...

CE - Biochemie

  • 2001 - 2004
    • •
  • 4 874 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • AV ČR
Projekt

The study of the thermodynamic stability of DNA modified by new anticancer platinum complexes (LZ1K03010)

associated with their ability to bind covalently to DNA. The effect of platinum adducts in the specific recognition of modified DNA by proteins that participate inthe anticancer on DNA will be evaluated. These nov...

BO - Biofyzika

  • 2003 - 2004
    • •
  • 1 066 tis. Kč
    • •
  • 799 tis. Kč
    • •
  • MŠMT
Projekt

Analyzing repair of toxic DNA-protein crosslinks in Arabidopsis (GA19-13848S)

External stress, specific metabolites and even regular developmental processes (e.g. meiotic recombination) lead to covalent entrapping of proteins to DNA and formation of DNA-protein crosslink (DPC). DPCs are highly toxic ...

Cell biology

  • 2019 - 2022
    • •
  • 7 651 tis. Kč
    • •
  • 7 651 tis. Kč
    • •
  • GA ČR
Projekt

Study of Mechanism of Molecular Recognition Application to Analytical and Medicinal Chemistry (VS97135)

knowledge of DNA and protein binding sides. Non-covalent complexes of macrocycle-modified oligonucleotides with DNA will be characterized by variety of spectroscopic methods. As ligands for DNA targeting macrocycl...

CB - Analytická chemie, separace

  • 1997 - 2000
    • •
  • 29 817 tis. Kč
    • •
  • 19 720 tis. Kč
    • •
  • MŠMT
  • 1 - 10 z 1 927