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2 385 (0,079s) •

Projekt

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on t...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Projekt

Ontogeny of pig enterleukin 18 production and its role in bacterial infections (GA524/02/1217)

bacteria). 4. Adjuvant effect of IL-18 in pig fetal DNA vaccine model. 5. ExpressionInterieukin 18 is a novel cytokine playing presumptive important role in anti. It is suggested to study: 1. IL-18 in the pig in p...

EC - Imunologie

  • 2002 - 2004
    • •
  • 3 391 tis. Kč
    • •
  • 2 267 tis. Kč
    • •
  • GA ČR
Projekt

Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)

It has been shown previously that complexing IL-2 with certain anti-IL-2 mAb enourmously increases activity of IL-2 in vivo. These immunocomplexes selectively stimulate different subsets of immune cells depending ...

EC - Imunologie

  • 2013 - 2018
    • •
  • 11 872 tis. Kč
    • •
  • 11 872 tis. Kč
    • •
  • GA ČR
Projekt

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e to understanding the mechanism how these complexes interact with high affinity trimeric IL-2 receptor. JES6-1 mAb sterically blocks the in...

Immunology

  • 2018 - 2022
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  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Projekt

Predictive immunological markers in patients with hepatitis C viral infection (NT14072)

in laboratory in Prague using FlowCytomix methodology: IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IFNg, TGF-b and TNF? and 4) Next imunological markers will be assessed......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
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  • 7 567 tis. Kč
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  • 7 567 tis. Kč
    • •
  • MZ
Projekt

The effect of anti IL-17 therapy on skin and gut microbiota and intestinal barrier function in psoriasis patients (NU22J-05-00056)

the effects of anti IL-17 therapy can ultimately affect the gut-skin axis and thus and function of the skin- and gut microbiota in the setting of anti IL-17 therapy should and systemic inflammation of psoriatic pa...

Immunology

  • 2022 - 2025
    • •
  • 6 524 tis. Kč
    • •
  • 6 524 tis. Kč
    • •
  • MZ
Projekt

HLA polymorphism and polymorphism of cytokine genes in pemphigus vulgaris (MEB080892)

Research aim of the project is to investigate gene polymorphism (single nucleotide polymorphisms), particularly of TH2 cytokines (IL-4, IL-5, IL-6) and proinflammatory cytokines (IL-1, TNF, IFN-γ) in ...

EE - Mikrobiologie, virologie

  • 2008 - 2009
    • •
  • 24 tis. Kč
    • •
  • 24 tis. Kč
    • •
  • MŠMT
Projekt

Potentiation of anti-tumor immunity with cytokine immnocomplexes during treatment with polymer-bound drugs (GP301/07/P192)

and to enhance the induction of anti-tumor immunity established during or shortly after the treatment. The immunomodulation will be provided in the form of IL-2/anti-IL-2 mAb or together with IL-12. Such ...

FD - Onkologie a hematologie

  • 2007 - 2009
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  • 1 464 tis. Kč
    • •
  • 1 464 tis. Kč
    • •
  • GA ČR
Projekt

Novel clinically relevant IL-2 immunotherapeutics for cancer treatment (GA20-13029S)

IL-2 (hIL-2) covalently linked to light chain of anti-hIL-2 mAb, functionallyMouse IL-2/S4B6 mAb complexes with potent stimulatory activity for memory CD8 IL-2. Potential clinical use of these complexes is limited...

Immunology

  • 2020 - 2022
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  • 12 596 tis. Kč
    • •
  • 12 596 tis. Kč
    • •
  • GA ČR
Projekt

Depletion of T regulatory cells without need of anti-CD25 mAb for effective chemoimmunotherapy by HPMA-based polymeric drugs and IL-2 immunocomplexes (GAP301/11/0325)

are depleted most often by anti-CD25 mAb, reflecting their dependency on IL-2 signal. However, anti-CD25 mAb can also eliminate subsequently activated T cells, including in circulation. Here we suggest first to activate Tr...

FD - Onkologie a hematologie

  • 2011 - 2015
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  • 17 039 tis. Kč
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  • 17 039 tis. Kč
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  • GA ČR
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