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2 090 (0,092s)

Projekt

The importance of infiltrating immunocompetent cells for the development of head and neck squamous cell carcinoma (NT11542)

Tumor infiltrating cells of the immune system, including tumor associated macrophages (TAM) and regulatory T lymphocytes (Treg) interact not only with tumor cells of interactions of tumor...

FF - ORL, oftalmologie, stomatologie

  • 2010 - 2015
  • 8 722 tis. Kč
  • 8 722 tis. Kč
  • MZ
Projekt

Antigen receptor rearrangement profiling in immune monitoring and treatment response prediction of malignant diseases (NU20-03-00284)

of infiltrating immune cells (mainly T lymphocytes) and a potential for immunotherapy., MRD and profile of immunoglobulin and T-cell receptor gene rearrangements in infiltrating physiological lymphocy...

Immunology

  • 2020 - 2023
  • 9 182 tis. Kč
  • 9 182 tis. Kč
  • MZ
Projekt

Genetically downregulated expression of the immune checkpoint inhibitor LAIR-1 in tumor-specific T cells as a novel strategy for breaking the resistance of solid tumors to adoptive T cell (NU23-08-00071)

tumor-specific T cells from the tumor-infiltrating lymphocytes or peripheral blood patients with solid tumors still do not benefit from this therapy. Adoptive T cell in the treatment of ...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2023 - 2026
  • 11 244 tis. Kč
  • 11 244 tis. Kč
  • MZ
Projekt

Correlation of immunotherapeutic molecular targets with gut microbiome in NSCLC patients (NV19-03-00069)

During the recent years, cancer immunotherapy has been rediscovered and in some cases of solid and haematological tumours also successfully implemented into the therapeutic strategy. Tumour infiltrating T lymphocytes exists...

Oncology

  • 2019 - 2022
  • 14 064 tis. Kč
  • 14 064 tis. Kč
  • MZ
Projekt

Molecular-biological and histopathological characteristics of tumor infiltrating lymphocytes as instrument of prediction of risk of early colorectal cancer recurrence (NT12025)

to the behavior of tumor infiltrating lymphocyte tissue between patients with colorectal...

FJ - Chirurgie včetně transplantologie

  • 2011 - 2014
  • 5 261 tis. Kč
  • 5 261 tis. Kč
  • MZ
Projekt

Predictive factors of pathologic response to neoadjuvant chemotherapy in patients with HER-2 positive or triple negative breast carcinoma (NT13564)

centers difference in tumor infiltrating lymphocytes in patients with different tumor and the presence of tumor infiltrating lymphocytes will be evaluated together with tumor re...

FD - Onkologie a hematologie

  • 2012 - 2015
  • 9 695 tis. Kč
  • 9 695 tis. Kč
  • MZ
Projekt

The prognostic predictive markers in penile carcinoma a molecular and morphological study. (NU21J-03-00019)

infiltrating T-lymphocytes, expression of programmed death ligand 1 (PD-L1) with possible to a metastatic disease and death of affected persons, whereas there is only a localized tumor potential from less aggressi...

Pathology

  • 2021 - 2024
  • 6 978 tis. Kč
  • 6 978 tis. Kč
  • MZ
Projekt

Combined immunotherapy of tumors with different expression of MHC class I molecules (GA16-04477S)

the viral E7 oncoprotein. Tumor-infiltrating cells, especially macrophages, myeloid-derived suppressor cells, NK cells, NKT cells, and T and B lymphocytesThis study will focus on the immunotherapy of tumors

EC - Imunologie

  • 2016 - 2020
  • 8 919 tis. Kč
  • 8 724 tis. Kč
  • GA ČR
Projekt

Immunohistochemical quantification of prognostic factors in ovarian cancer and correlation with clinical history of the disease (NR8363)

kinetics, angiogenic potential, and presence of tumour-infiltrating T cells in ovarian...

FK - Gynekologie a porodnictví

  • 2005 - 2007
  • 731 tis. Kč
  • 675 tis. Kč
  • MZ
Projekt

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

anti-tumor T-lymphocytes at patients with multiple myeloma. Clinical partThe aim of this project is to find an optimal strategy of T cell stimulation cells, myeloma mRNA or peptides derived from tumor ass...

FD - Onkologie a hematologie

  • 2006 - 2009
  • 6 929 tis. Kč
  • 6 587 tis. Kč
  • MZ
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