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7 694 (0,125s) •

Projekt

Enzymes and Mechanisms of Microbial Degradation of Nitroaromatic Compounds (GAP503/11/0163)

Investigation of enzymes participating in microbial degradation of nitroaromatic compounds. Expression of nitro-reductases, monooxygenases, dioxygenases enzymes participating in reduction and oxidation catabolic reactions. Screening...

CE - Biochemie

  • 2011 - 2013
    • •
  • 5 104 tis. Kč
    • •
  • 5 104 tis. Kč
    • •
  • GA ČR
Projekt

Mechanism of ligand access/egress to/from active site of microsomal drug-metabolising cytochromes P450 (GPP303/12/P019)

The microsomal cytochromes P450 (CYPs) are enzymes capable of metabolizing metabolism in liver. The structure of the CYP enzyme contains buried active site the substrate specificity of the CYP enzymes and they also affect k...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2014
    • •
  • 976 tis. Kč
    • •
  • 976 tis. Kč
    • •
  • GA ČR
Projekt

Functional role of oxysterols in plant photosynnthesis (GAP501/11/1650)

Small molecule enzyme activators enable us to better understand the endogenous principles of enzyme activation and their allosteric mechanisms. To activate an enzyme, they often bind to an allosteric site at the ca...

CE - Biochemie

  • 2011 - 2014
    • •
  • 5 850 tis. Kč
    • •
  • 5 850 tis. Kč
    • •
  • GA ČR
Projekt

Metabolism of terpenes and mechanisms of their toxic effects in human liver (GA18-09946S)

and sesquiterpenes, with aim to obtain new information about mechanisms of actions enzymes, xenobiotic-metabolizing enzymes and microRNAs regulating translation of these enzymes. Human precision-cut liver slices a...

Pharmacology and pharmacy

  • 2018 - 2021
    • •
  • 5 414 tis. Kč
    • •
  • 5 414 tis. Kč
    • •
  • GA ČR
Projekt

Study of degradation of endocrine disruptors by ligninolytic fungi (KJB600200613)

is available about application of LF and about mechanism of the degradation. The objectives and to clarify the mechanism. The degradation will be performed with bisphenol conditions. Activities of ligninolytic enzymes and ...

DK - Kontaminace a dekontaminace půdy včetně pesticidů

  • 2006 - 2008
    • •
  • 1 270 tis. Kč
    • •
  • 1 270 tis. Kč
    • •
  • AV ČR
Projekt

Biochemical and structural comparisons of two differentially targeted cytokinin dehydrogenase enzymes (ME 861)

understanding of mechanism of signalisation of cytokinins, study of regulation of cytokinin level at the level of plant tissue and cell...

CE - Biochemie

  • 2006 - 2009
    • •
  • 2 152 tis. Kč
    • •
  • 1 976 tis. Kč
    • •
  • MŠMT
Projekt

Aging of the eye The role of oxidative, mechanical and hypoxic stress. Pramature aging of the eye and new approaches of prevention (NG16)

The rle of oxidative,hypoxic and mechanical stress on aging agents and newly developed contact lenses producing minimal hypoxic and mechanical stress. Age-related differences in the healing of eye lesions,enzymes as markers...

FF - ORL, oftalmologie, stomatologie

  • 1998 - 2000
    • •
  • 3 500 tis. Kč
    • •
  • 2 868 tis. Kč
    • •
  • MZ
Projekt

Role of BMH proteins in the regulation of yeast enzyme neutral trehalase (GAP207/11/0455)

–dependent regulation of the activity ofthe enzyme Neutral trehalase (NTH1). Site spectroscopy, X-raycrystallography, analytical ultracentrifugation and enzyme and is required in a variety stress conditions. Activity of theNTH1 ...

CE - Biochemie

  • 2011 - 2015
    • •
  • 5 975 tis. Kč
    • •
  • 5 975 tis. Kč
    • •
  • GA ČR
Projekt

Mechanism of 17?-ethinylestradiol degradation by enzymes of ligninolytic fungi (GAP503/10/0408)

is aimed at the characterization of 17?-ethinylestradiol (EE2) degradation mechanism enzymes. Degradation metabolites will be identified using HPLC-MS and GC-MS. Moreover, the effect of EE2 or its metabolites on the production of f...

CE - Biochemie

  • 2010 - 2012
    • •
  • 2 595 tis. Kč
    • •
  • 2 595 tis. Kč
    • •
  • GA ČR
Projekt

Mechanisms of biodegradation of environemntal organopollutants by ligninolytic fungi (IAA6020411)

by poor knowledge of the degradation mechanisms involved. The project will specify contribution of the indivitual mechanisms (ligninolytic enzymes, cytP450 oxygenase in liquid media.Comparison of enzyme activities...

EE - Mikrobiologie, virologie

  • 2004 - 2008
    • •
  • 3 753 tis. Kč
    • •
  • 3 753 tis. Kč
    • •
  • AV ČR
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