Filtry
Delineating the role of HTT Cis-Variants in the pathogenesis of Huntington disease (9F24002)
Huntington disease (HD) is a fatal neurodegenerative disorder without disease modifying therapies. It is well known that HD is always caused by an expanded CAG repeat in the huntingtin (HTT) gene leading to translation of a mutant HTT
Other clinical medicine subjects
- 2024 - 2027 •
- 5 918 tis. Kč •
- 5 918 tis. Kč •
- MŠMT
Řešení projektu: 1. 6. 2024 - 31. 5. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
OPPIK Applications - HTT SERVICES (EG20_321/0024375)
This is research and development of a prototype device (rotary positioner with heating) for high-temperature heating for the production of rotary weldments with innovative utility properties and welding of carbide welds on these weldments. (The rotar...
Mechanical engineering
- 2021 - 2022 •
- 4 908 tis. Kč •
- 0 tis. Kč •
- MPO
Řešení projektu: 1. 1. 2021 - 24. 11. 2022
Uznané náklady
Podpora ze státního rozpočtu (0%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Preparation of carbon materials with separation abillity (ME 163)
Microporous membranes (also supported) were prepared by control carbonization of resits and polysiloxanes. Influence of HTT on sorption capacity, microporous volume, microporous size and transport properties were studied. Evaluations of CO2 ...
JI - Kompositní materiály
- 1998 - 1999 •
- 712 tis. Kč •
- 300 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 1998 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (42%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Autophagy in pathogenesis of Huntington's disease (GA22-24983S)
Huntington’s disease (HD) is a deadly hereditary neurodegenerative disorder, caused by an expansion of CAG tract in the huntingtin gene (HTT) over 36 repeats. Expanded stretch of glutamines at the N-terminus of HTT protein changes i...
Cell biology
- 2022 - 2024 •
- 9 027 tis. Kč •
- 9 027 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Comparative study of Huntington's disease using biochemical, immunocytochemical and molecular genetic methods on the mouse, minipig and human tissues and cells (7F14308)
The grant proposal is based on comparative studies of tissues (mainly from brain), somatic cells (skin fibroblasts) and germ cells (spermatozoa) isolated from mice (R6/2) and minipigs transgenic for N-terminal part of human mutated HTT (TgHD...
EB - Genetika a molekulární biologie
- 2014 - 2017 •
- 23 144 tis. Kč •
- 23 144 tis. Kč •
- MŠMT
Řešení projektu: 15. 7. 2014 - 30. 4. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Modified oligonucleotides derived from 5´-substituted nucleoside 5´-C-phosphonates synthesis and hybridization properties (GP203/04/P273)
Modified oligonucleotides containing the 3´-O-P-CH(R)-5´´ internucleotide linkages derived from 5´-substituted nucleoside 5´-C-phosphonates in the project, and their physico-chemical properties will be studied and the influ...
CC - Organická chemie
- 2004 - 2006 •
- 806 tis. Kč •
- 806 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of STAT 5 protein in cytokine-mediated signaling in normal and malignant human breast epithelium (KJB502070601)
some questions arising from the idea that STAT 5 (signal transducer and activator of transcription 5) may be involved in interferon and estrogen signaling pathways in breast epithelial cells and its functional abnormalities of STAT...
EB - Genetika a molekulární biologie
- 2006 - 2007 •
- 590 tis. Kč •
- 590 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2006 - 1. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
Individual 5-fluorouracil dose individualization in patients with colorectal cancer (NS9693)
The objective of the research is to verify the potential importance of 5-FU pharmacokinetic characteristics and biomarkers reflecting the genetic polymorphism of enzymes involved the efficacy of the drug. The goal is to predict the drug dose...
FR - Farmakologie a lékárnická chemie
- 2008 - 2011 •
- 7 470 tis. Kč •
- 7 257 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Ministerstvo zdravotnictví
New derivatives of 5-azacytosine nucleosides like demethylating therapeutics identification of clinical candidates and efficiency biomarkers. (FR-TI4/625)
The project is focused to the development of new hypomethylating agents based on polymer conjugates of 5-azacytosine nucleosides and their 5,6-dihydro congeners, which will increase plasma half-life of the drug. This will not only pronounce ...
FD - Onkologie a hematologie
- 2012 - 2015 •
- 31 955 tis. Kč •
- 25 152 tis. Kč •
- MPO
Řešení projektu: 1. 1. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (79%)
Poskytovatel: Ministerstvo průmyslu a obchodu
A novel cariprazine-derived D2/5-HT3 receptor modulators with potential implications for the treatment of schizophrenia and depressive symptoms (GN24-11191O)
, used mainly to alleviate positive symptoms. Due to the high expression of 5-HT3 function, 5-HT3Rs represent a suitable target for influencing the negative and cognitive symptoms of schizophrenia. Thus, 5-HT3R antagonists ...
Pharmacology and pharmacy
- 2024 - 2027 •
- 5 178 tis. Kč •
- 5 178 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2024 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
- 1 - 10 z 1 520