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823 (0,188s)

Projekt

Research and development of bacteriophage lytic enzymes to conrol staphylococcal infections (FR-TI4/417)

of lytically active enzymes exploitable as antimicrobial preparations for therapy with broad hostrange encoding lytic enzymes will be optimized by gene engineering methods to enhance their lytic activity. A set of gene con...

EC - Imunologie

  • 2012 - 2015
  • 9 845 tis. Kč
  • 4 516 tis. Kč
  • MPO
Projekt

Research of broad host-range mutants of staphylococcal bacteriophages (TA01010405)

The aim of the proposed project is development of a stable phage preparation containig as a effective compound the novel phage mutants with lytic activity towards multidrug resistant Staphylococcus aureus strains. The lysis-optimized host-ra...

EE - Mikrobiologie, virologie

  • 2011 - 2015
  • 10 297 tis. Kč
  • 7 764 tis. Kč
  • TA ČR
Projekt

Electron Transfer in Cellulose Degrading Enzymes (GF16-34818L)

The proposed project is aimed at elucidation of interactions between cellobiose dehydrogenase (CDH) and its putative redox partner – lytic polysaccharide monooxygenase (LPMO) – in solution and in their cellulose bound state. Our research str...

CE - Biochemie

  • 2016 - 2020
  • 3 288 tis. Kč
  • 3 288 tis. Kč
  • GA ČR
Projekt

VACCINIA VIRUS INFECTION TYPE OF HOST-CELL DEATH, CHANGES OF ITS METABOLISM AND REDOX POTENTIAL (GA310/05/0477)

typical markers of necrosis in lytic infection of epithelial cells. However of activation of certain elements of the apototic cascade during lytic infection by......

EE - Mikrobiologie, virologie

  • 2005 - 2007
  • 2 780 tis. Kč
  • 2 556 tis. Kč
  • GA ČR
Projekt

Development of various formulations containing bacteriophages associated with the production of nasal spray used in the prevention of MRSA. (EG21_374/0027103)

The project will focus on the development of formulations, in the form of pilot plant, enabling various applications of phages and ensuring the maintenance of their highest lytic activity and maximum stability. Furthermore, the project will ...

Pharmacology and pharmacy

  • 2021 - 2024
  • 9 047 tis. Kč
  • 0 tis. Kč
  • MPO
Projekt

Food pathogens (Bacillus strain) in milk, method for estimate and reduction of their passage into the foodstuff chain (EP9058)

The proposed project would study frequency of spore-forming Bacillus strains in raw cow's milk and formation of lipolytic and proteolytic enzymes. Survival of pathogens (as spores) at pasteurization temperatures and formation of lytic enzyme...

GM - Potravinářství

  • 1999 - 2002
  • 1 700 tis. Kč
  • 1 350 tis. Kč
  • MZe
Projekt

The therapeutic effect of bacteriophages and their endolysins on opportunistic bacterial infections forming biofilm (FW01010350)

The aim of the project is to build a pilot plant; proven technology for opportunistic bacterial infections caused by Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae, E. coli, Haemophillus influenzae, bio...

Infectious Diseases

  • 2020 - 2024
  • 91 176 tis. Kč
  • 63 205 tis. Kč
  • TA ČR
Projekt

Combined phage therapy for supporting the treatment of chronic respiratory diseases. (FW10010112)

A mixture of antibiotics suitable for inhalation and lytic bacteriophages active against the species S. aureus and P. aeruginosa will be prepared and tested. Testing of the product will be provided together with Masaryk University (MU) to fo...

Infectious Diseases

  • 2024 - 2026
  • 9 755 tis. Kč
  • 6 821 tis. Kč
  • TA ČR
Projekt

Development of a substance based on the principle of phage therapy and advanced biocompatible materials to suppress staphylococcal infections of the skin of dogs and cats (FW12010450)

The goal of the project is to develop phagotherapeutic preparations on biocompatible carriers that will be used to suppress staphylococcal skin infections of dogs and cats. The consortium of applicants divided the project into three stages, within wh...

Virology

  • 2025 - 2027
  • 19 200 tis. Kč
  • 13 425 tis. Kč
  • TA ČR
Projekt

Genetic indicators in children with ADHD in relation to selected parameters of MR imaging and spectroscopy (NT14177)

with DAT1 polymorphisms 10/10 will be measured by the volume of nucleus caudatus and nucleus lenticularis is the smallest in patients with polymorphisms of DAT1 10/10 the volume of caudate nucleus in the DAT1 ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013 - 2015
  • 4 678 tis. Kč
  • 4 678 tis. Kč
  • MZ
  • 1 - 10 z 823