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5 355 (0,086s) •

Projekt

The role of free radicals in pathogenesis of preeclampsia (IZ2776)

FK - Gynekologie a porodnictví

  • 1995 - 1997
    • •
  • 1 676 tis. Kč
    • •
  • 1 676 tis. Kč
    • •
  • MZ
Projekt

Selenium status of elderly and possibilities of its improvement. (NG19)

Selenium status and intake determination of elderly in the CR will be perormed by the analyses of serum Se, urine Se, diet, and GPx. The correction of supposed Se deficiency will be proposed for elderly, according the results of Se supplemen...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
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  • 3 573 tis. Kč
    • •
  • 2 917 tis. Kč
    • •
  • MZ
Projekt

Selenium Intake in ČR and Improvement of Selenium Deficiency by supplementation. (NB4845)

Se, urine Se, GPx) as well as I and thyroid hormones will be measured during Se...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 3 367 tis. Kč
    • •
  • 2 699 tis. Kč
    • •
  • MZ
Projekt

Changes of selected metabolites in the course of optimalization of selenium in the organism (NR7820)

Deficiency of selenium proved in the ČR may worsen health estate of the population by increase of frequency of "oxidative" diseases as well as infectious diseases through decrease of GPx activity - increase of Se intake might eliminate this ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2007
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  • 4 507 tis. Kč
    • •
  • 4 221 tis. Kč
    • •
  • MZ
Projekt

Examination of antioxidant status and some polymorphisms of paraoxonase1 in patients with different diseases of pancreas (NS9769)

(GPX), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 6 081 tis. Kč
    • •
  • 6 081 tis. Kč
    • •
  • MZ
Projekt

Role of Lineage Specific Transcription Factors GATA-1 and PU.1 in Hematopoietic Commitment and Leukemogenesis (GA301/06/1093)

GATA-1 and myeloid PU.1, is thought to transcriptionally regulate lineage commitment in chromatin. PU.1 plays a role in cancer: high levels of transcription factor PU.1 has beenshown to cause erythroleukemia where...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 5 021 tis. Kč
    • •
  • 4 989 tis. Kč
    • •
  • GA ČR
Projekt

The study of relation between the activity of type - V collagenase and level of s-ICAM1 and s-VCAM1 in sera and synovial fluids to the prognosis of rheumatoid arthritis (NK6332)

A study will be made of the content and activity of gelatinase B and the levels of the soluble forms of immunoglobulins ICAM-1 and VCAM-1 in the blood serum and in the synovial fluid of patients with early rheumatoid arthritis. In t...

FE - Ostatní obory vnitřního lékařství

  • 2000 - 2002
    • •
  • 1 831 tis. Kč
    • •
  • 1 831 tis. Kč
    • •
  • MZ
Projekt

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of IFN-I. Exposure of pDCs to HIV-1-infected lympho...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Projekt

Novel regulatory mechanisms of transcription factors PU.1 and GATA-1 in leukemogenesis. (GPP301/12/P380)

determinants such as transcription factor PU.1 regulating most of the hematopoietic target genes. Production of mature blood elements requires connecting PU.1 with secondary determinants such as GATA-1 and other lineage sp...

FD - Onkologie a hematologie

  • 2012 - 2016
    • •
  • 3 726 tis. Kč
    • •
  • 3 726 tis. Kč
    • •
  • GA ČR
Projekt

Genetic predisposition to osteoporosis. (NB7380)

An analysis of the association between common polymorphisms in the transforming growth factor beta -1, plasminogen-activator inhibitor and collagen type 1 genes and osteoporosis.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 574 tis. Kč
    • •
  • 2 573 tis. Kč
    • •
  • MZ
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