Filtry
Next generation CAR-T cells for the therapy of hematological malignancies (NU23-03-00188)
malignancies such as AML, B-ALL and B-NHL using CAR-T T lymphocytes. The aim of the project is to build on the ongoing clinical study with CD19-specific CAR-T lymphocytes, which trial in patients with re...
Hematology
- 2023 - 2026 •
- 13 368 tis. Kč •
- 13 368 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2023 - 31. 12. 2026
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The use of stem cells for induction of specific transplantation tolerance (GA19-02290S)
of tolerance and point out the role of regulatory T and B lymphocytes. The recent data of skin allografts. The project will show new possibilities to use unique properties......
Transplantation
- 2019 - 2022 •
- 6 464 tis. Kč •
- 6 464 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Characterization of T and B lymphocytes in Ileal Peyers Patches of swine. (ME09089)
in B cell diversification and to characterize B and T cell subsets in this organ. conversion events and diversification of B cell repertoire is expected due to occurrence in diversification of B cell repe...
EC - Imunologie
- 2009 - 2012 •
- 3 738 tis. Kč •
- 3 738 tis. Kč •
- MŠMT
Řešení projektu: 1. 4. 2009 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Lymphocyte subpopulatins in patients with humoral immunodeficiencies (NR7981)
T- and- B- cell surface markers, namely those known to be abnormal in patients with common variable immunodeficiency (CVID), will be analysed in patients with selective IgA deficiency, selective IgM deficiency and CVID. The results ...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2004 - 2006 •
- 1 682 tis. Kč •
- 1 668 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Characterization of B lymphocyte subpopulations in patients with common variable immunodeficiency. (NR9198)
of transitional and immature (CD21-) B cells in patients with CVID and comparison of the found transitional and immature (CD21-)B cells of CVID patients and controls. Correlation between of the number of naive, effector and memory ...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2007 - 2009 •
- 6 789 tis. Kč •
- 6 768 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
T and B cell immune response in PRRSV, SIV and PCV2 infected piglets (GA523/07/0088)
, specifically the response of T and B cells since they are a crucial element of adaptive anti-viral immunity. This is a proposal to examine and compare the T and B cell......
GJ - Choroby a škůdci zvířat, veterinární medicina
- 2007 - 2009 •
- 2 929 tis. Kč •
- 2 929 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of gammadelta T cells in immunization of porcine naive immune system (GAP502/12/0110)
of porcine gamadelta T and B cells was recently described by our group and sequences of T by chicken ovalbumine leads to expansion and diversification of gamadelta T cells. In this project we propose to examine th...
GJ - Choroby a škůdci zvířat, veterinární medicina
- 2012 - 2016 •
- 8 914 tis. Kč •
- 8 914 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)
Chimeric Antigen Receptor (CAR) T cells achieved remarkable success in treating B-cell malignancies, yet, their long term efficiency does not hold up to the original promises. Novel designs of CAR-T cells are urgently neede...
Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
- 2022 - 2024 •
- 8 916 tis. Kč •
- 8 814 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
The regulation of immunity in syndrome diGeorge (NT13287)
functions. We plan to investigate in a prospective study not only T cells that were in past studied in detail, but also B cells potentially affected by impaired T cells help. We also plan to investigate T regulato...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2012 - 2015 •
- 9 183 tis. Kč •
- 9 183 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The role of T- and R-conformations of insulin in binding to the insulin receptor (GPP207/11/P430)
must undergo structural changes in the C-terminus of the B-chain upon binding to the IR. In addition, the N-terminus of the B-chain may adopt two different conformations, including T and R. Until now, the biological releva...
CE - Biochemie
- 2011 - 2013 •
- 2 554 tis. Kč •
- 2 554 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
- 1 - 10 z 2 455