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1 652 (0,173s) •

Projekt

Genome stability in mammalian oocytes and somatic cells (GF21-42225L)

, we focus on the single-strand DNA breaks (SSBs): These are the most common insults and can lead to deleterious double-strand breaks if unrepaired. To analyze......

Reproductive biology (medical aspects to be 3)

  • 2021 - 2024
    • •
  • 6 381 tis. Kč
    • •
  • 6 381 tis. Kč
    • •
  • GA ČR
Projekt

Conjugates of nucleobases with metal complexes as electroactive markers. Application of labelled oligonucleotides in electrochemical DNA sensors (GA203/05/0043)

in their single-stranded as well as double-stranded forms (including duplexes involving single...

CC - Organická chemie

  • 2005 - 2007
    • •
  • 2 967 tis. Kč
    • •
  • 2 967 tis. Kč
    • •
  • GA ČR
Projekt

The source of neurological pathology in PNKP-mutated disease (GN23-07330I)

Hereditary mutations in the DNA strand break repair protein polynucleotide kinase-phosphatase (PNKP) result in a spectrum of neuropathologies, ranging from mild neurodegeneration to severe neurodevelopmental dysfunction. PNKP is implicated i...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2025
    • •
  • 5 499 tis. Kč
    • •
  • 5 499 tis. Kč
    • •
  • GA ČR
Projekt

Chirality-selective electron transport in single molecular devices (GA24-11064S)

on electron transport through single helical molecules and helical polymer strands-induced spin-selectivity from our well-defined approach of single molecule studies.......

Physical chemistry

  • 2024 - 2026
    • •
  • 8 489 tis. Kč
    • •
  • 8 485 tis. Kč
    • •
  • GA ČR
Projekt

The use of plants in monitoring of human DNA damage. (LTC17047)

We propose to use the plants, and particularly their generally viable repair mutants, as supplemental model system to human biomonitoring by comet assay. We expect important input to interpretation of DNA damage and mutagenesis by combined action of ...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 3 010 tis. Kč
    • •
  • 3 010 tis. Kč
    • •
  • MŠMT
Projekt

New approaches in development of electrochemical sensors for DNA damage (GA203/04/1325)

intoDNA strand breaks or single-stranded regions that can be detected with a high...

CG - Elektrochemie

  • 2004 - 2006
    • •
  • 2 707 tis. Kč
    • •
  • 2 707 tis. Kč
    • •
  • GA ČR
Projekt

Effect of high LET radiation on specific interaction of proteins with DNA. (LD12008)

The main objective of the project is to determine how radiation damage to repair proteins modifies kinetics and fidelity of repair mechanisms in cells. Key proteins involved in the repair processes of DNA damaged bases and single strand<...

BO - Biofyzika

  • 2012 - 2014
    • •
  • 1 470 tis. Kč
    • •
  • 1 470 tis. Kč
    • •
  • MŠMT
Projekt

The influence of higher-order chromatin structure on the mechanism of DNA double-strand break (DSB) repair and formation of chromosomal translocations in cells irradiated with gamma rays (LD12039)

double-strand breaks (DSBs) between cells irradiated with selected ion (micro)beams cellular response to single and fractionated irradiation with the same total dose......

BO - Biofyzika

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Projekt

Intrinsic properties of RAD51 filament and its biological regulations (GA17-17720S)

Homologous recombination (HR) is an essential mechanism for the repair of DNA double-strand breaks and damaged replication forks. HR is initiated by the formation of a RAD51 helical nucleoprotein filament on single stranded...

CE - Biochemie

  • 2017 - 2019
    • •
  • 9 372 tis. Kč
    • •
  • 8 937 tis. Kč
    • •
  • GA ČR
Projekt

Formation, structure and dynamics of biologically significant complexes. Probing via vibronic transitions in key molecules. (ME 557)

Support of a collaboration project with the Institute for Molecular Science, Okazaki, on visible and UV resonance Raman studies of important biomolecular complexes. Particularly, complexes of cationic porphyrins with single- and double-s...

BO - Biofyzika

  • 2002 - 2004
    • •
  • 2 305 tis. Kč
    • •
  • 980 tis. Kč
    • •
  • MŠMT
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