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9 109 (0,099s)

Projekt

A-204C polymorphism and regulation of cholesterol 7alpha-hydroxylase activity (NR8987)

Circadian variation in cholesterol 7alpha-hydroxylase (CYP7A1) activity will be studied in healthy volunteers homozygous either for -204A or -204C variant in CYP7A1 gene promoter. Circadian variation in CYP7A1 activity<...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
  • 3 917 tis. Kč
  • 3 599 tis. Kč
  • MZ
Projekt

The role of the STAT signalling pathway in the rat circadian system (GAP303/12/1137)

neurons and via cell signalling pathways leads to transcriptional activation of clock genes and subsequent phase shifts of circadian rhythmicity. Our preliminary experiments revealed high expression of the signal transducer and

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
  • 3 757 tis. Kč
  • 3 757 tis. Kč
  • GA ČR
Projekt

Metabolomics 2.0 Comprehensive analytical methods and bioinformatics tools for the study of circadian rhythms (LTAUSA19124)

The aim of this project is to establish cooperation and active scientific activity between the Laboratory of Translational Metabolism, Laboratory of Metabolomics tools for the study of circadian rhythms. Recent improvements...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2020 - 2022
  • 7 740 tis. Kč
  • 7 740 tis. Kč
  • MŠMT
Projekt

The crosstalk between the endocannabinoid and circadian systems (GA17-14704S)

in this regard were so far unsuccessful. The circadian system (CDS) was linked the ECS in a circadian manner and examine its role in central and peripheral clock mice, cell lines) models and focus on circadian behavior, ge...

ED - Fyziologie

  • 2017 - 2021
  • 4 884 tis. Kč
  • 4 695 tis. Kč
  • GA ČR
Projekt

Glutamate receptors expression within the rat suprachiasmatic nuclei, the circadian regulation and receptor subunits function in the circadian clock e (GAP303/10/1227)

mechanism is not uniform, it is modified by circadian time, ontogenetic development or by activation of other brain pathways connected with the SCN. The process of entrainment undergo spontaneous or light-induced  changes within th...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
  • 2 481 tis. Kč
  • 2 481 tis. Kč
  • GA ČR
Projekt

Insight into the circadian system of the spontaneously hypertensive rat (SHR) during ontogenesis and in adulthood (GAP303/11/0668)

The mammalian circadian system exhibits a temporal control over physiological functions, including energy metabolism. Perturbation of the circadian organization may backon the circadian system. The spontaneously hypertensiv...

ED - Fyziologie

  • 2011 - 2013
  • 4 920 tis. Kč
  • 4 920 tis. Kč
  • GA ČR
Projekt

Functional genetic analysis of insect circadian clock (GA204/04/0862)

Circadian biological clocks represent fascinating time-keeping devices insect model for genetic and molecular dissection of the circadian rhythmicity. Since the inherent properties of circadian clocks evident among all meta...

EB - Genetika a molekulární biologie

  • 2004 - 2006
  • 2 166 tis. Kč
  • 2 166 tis. Kč
  • GA ČR
Projekt

Impact of chronodisruption on the function of choroid plexus and the possibility of intervention by diet regime in both sexes (GA25-16337S)

to chronodisruption (CD), which impairs the ability of the circadian system to control found that the mouse ChP's circadian clock controls most of the ChP functions techniques, including circadian metabolomics, lipidomics,...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2025 - 2027
  • 9 329 tis. Kč
  • 9 220 tis. Kč
  • GA ČR
Projekt

Circadian regulation of kynurenine pathway enzymes in rat brain and peripheral organs (GA23-07184S)

. The circadian system is a homeostatic mechanism that regulates most physiological processes with the disruption of the kynurenine pathway. Our preliminary results show the circadian rhythms with disrupted circadian system...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2023 - 2025
  • 7 392 tis. Kč
  • 7 392 tis. Kč
  • GA ČR
Projekt

Mapping of the rat circadian metabolome in brain and peripheral tissues during embryonic to postnatal development (GA20-21114S)

The circadian rhythmicity during embryonic and postnatal development has been of the circadian variation of the clock genes has been demonstrated. However, until now no study has focused on studying circadian rhythmicity du...

Developmental biology

  • 2020 - 2022
  • 6 902 tis. Kč
  • 6 902 tis. Kč
  • GA ČR
  • 1 - 10 z 9 109