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7 058 (0,084s) •

Projekt

Donor derived free cell DNA as a diagnostic marker of acute rejection in orthotopic heart transplant recipients (NR8547)

The aim of this study is to evaluate the utility of donor derived free cell DNA detection in heart transplant recipients serum in acute rejection diagnosis.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
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  • 2 080 tis. Kč
    • •
  • 1 953 tis. Kč
    • •
  • MZ
Projekt

Effects of ligands on DNA damage induced by free radicals. (OC09012)

. The existing stochastic model of DNA damage caused by free radical attack will be furtherDNA attack by radical species produced by water radiolysis is the most is to follow yields and distributions of DNA damages...

BO - Biofyzika

  • 2009 - 2011
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  • 465 tis. Kč
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  • 465 tis. Kč
    • •
  • MŠMT
Projekt

Use of cfDNA as a new intention for minimally-invasive diagnosis and precise molecular classification of colorectal tumors. (NT14383)

Prospective study aimed at development and application of molecular methods for the investigation of genetic and epigenetic biomarkers in free tumor DNA (cell-free tumor DNA) for early diagnosis and molecu...

FE - Ostatní obory vnitřního lékařství

  • 2013 - 2015
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  • 9 070 tis. Kč
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  • 7 796 tis. Kč
    • •
  • MZ
Projekt

Use of the real-time PCR for fetal DNA analysis in maternal plasma (GA203/03/1025)

aquantification of cell-free fetal DNA in maternal plasma and performing of non-invasive fetusProject is focused on establishing of new molecular DNA analysis methods (real-time quantitative PCR and genomic DN...

EB - Genetika a molekulární biologie

  • 2003 - 2005
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  • 1 800 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • GA ČR
Projekt

Structure, biology and medical potential of blood plasma-derived ultra-short cell-free DNA (GF22-04242L)

Fragments of DNA are constantly being released into the human blood circulation following cell death and by active secretion. The fragmentation of cell-free DNA (cfDNA) in blood plasma reflects its tissue ...

Oncology

  • 2022 - 2025
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  • 10 272 tis. Kč
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  • 9 732 tis. Kč
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  • GA ČR
Projekt

The possibility of using free circulating gDNA and mtDNA in the detection of graft rejection after heart transplantation. (NU20-06-00061)

Although improved surgical techniques and the development of new immunosuppressive drugs significantly extend the survival of heart transplant recipients, acute rejection remains a mortality risk during the first three years following cardiac transpl...

Transplantation

  • 2020 - 2024
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  • 7 503 tis. Kč
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  • 7 375 tis. Kč
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  • MZ
Projekt

Circulating nucleic acids as markers of multiple myeloma progression (NV15-29508A)

RNA (lncRNA) and cell-free DNA (cfDNA) have been described in peripheral blood that their levels mirror MM progression. Specific cfDNA originate directly from tumor cells......

FD - Onkologie a hematologie

  • 2015 - 2018
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  • 9 514 tis. Kč
    • •
  • 9 514 tis. Kč
    • •
  • MZ
Projekt

Use of New Molecular Genetic Methods for the Early Detection of Disease Progression in Patients with Resectable, Primary Colorectal Carcinoma Based On Circulating Tumor Cells and Free Tumor Nucleic (NS9809)

Project is directed at detection of circulating tumor cells and free circulating tumor nucleic acids from peripheral blood of patients. The examinations will be based on most recent techniques for imunomagnetic enrichment of cancer ...

FE - Ostatní obory vnitřního lékařství

  • 2008 - 2011
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  • 7 755 tis. Kč
    • •
  • 7 755 tis. Kč
    • •
  • MZ
Projekt

Deciphering Origins of DNA replication in genome integrity (GM22-20303M)

DNA replication is fundamental to cell proliferation, but its malfunctions can cause genome instability and trigger diseases including cancer. DNA replication origins is a key component of error-free DNA r...

Cell biology

  • 2022 - 2026
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  • 24 928 tis. Kč
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  • 24 928 tis. Kč
    • •
  • GA ČR
Projekt

Plasma free DNA - diagnostic and prognostic marker in child and adult critical illness. (ND7177)

and qualitative DNA determination. The correlation between free DNA level and systemic inflammatory response in children and adults. Estimation the value of free DNA profile the correlation of clinical co...

EB - Genetika a molekulární biologie

  • 2002 - 2004
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  • 2 149 tis. Kč
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  • 2 059 tis. Kč
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  • MZ
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