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17 (0,054s)

Výsledek výzkumu

Glia and volume transmission during physiological and pathological states

Extrasynaptic communication between neurons or neurons and glia is mediated by the diffusion of neuroactive substances through the extracellular space (ECS). Plastic changes in ECS volume, geometry and anisotropy significantly affect the spatial rela...

FH - Neurologie, neurochirurgie, neurovědy

  • 2005
  • Jx
Výsledek výzkumu

Extracellular matrix glycoproteins and diffusion barriers in human astrocytic tumours

The increasing proliferative activity of the human brain tumors correlated with the increase of the extracellular volume and tortuosity, which is associated with the overproduction of some ECM molecules, particularly of tenascin......

FH - Neurologie, neurochirurgie, neurovědy

  • 2004
  • Jx
Výsledek výzkumu

Extracellular matrix and diffusion barriers in human astrocytic tumors

Extracellular matrix and diffusion barriers in human astrocytic tumors...

FH - Neurologie, neurochirurgie, neurovědy

  • 2004
  • Jx
Výsledek výzkumu

The relationship between changes in intrinsic optical signals and cell swelling in rat spinal cord slices.

The relationship between changes in intrinsic optical signals, extracellular space diffusion parameters and extracellular potassium was studied on rat spinal cord slices during electrical stimulation and the application of elevated potassium, NMDA or...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003
  • Jx
Výsledek výzkumu

Diffusion Parameters of the Extracellular Space in Human Gliomas.

The diffusion parameters in temporal cortical tissue resected during surgical treatment of temporal lobe epilepsy (control) were compared with those in brain tumors and tumor slices were histopathologically classified. Tumor malignancy grade strongly...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003
  • Jx
Výsledek výzkumu

Water ADC, extracellular space volume and tortuosity in the rat cortex after traumatic injury

NMR and diffusion measurements in cortical stab wounds revealed a decrease in extracellular space volume near the wound and a wide-spread increase in extracellular matrix expression, accompanied by impaired diffusion of water and small molecul......

FP - Ostatní lékařské obory

  • 2002
  • Jx
Výsledek výzkumu

Changes in astrocytic structure in rat hippocampus evoked by activation of glutamate receptors and learning.

Stimulation by NMDA application or learning alters astrocytic structure.

FH - Neurologie, neurochirurgie, neurovědy

  • 2001
  • B
Výsledek výzkumu

Neuron-glia communication by extrasynaptic transmission.

Dynamic changes in ECS ionic composition, volume and geometry accompany neuronal activity, neuronal loss, glial development and proliferation, aging, CNS injury, anoxia/ischemia, spreading depression, tumors, inflammation dyemyelination and many othe...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001
  • B
Výsledek výzkumu

Extracellular space volume fraction and geometry in human cortex and glial tumors.

Ecs diffusion parameters in human temporal cortex similar to those previously determined in rat cortex. Volume fraction ? and tortuosity ? are increased in astrocytic gliomas and the higher the glioma s WHO grade the greater the ECS volume and tortuo...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001
  • B
Výsledek výzkumu

Alterated diffusion parameters in the brain with kaolin-induced hydrocephalus.

Compression of the ECS in the cerebral cortex following induction of hydrocephalus, slows down the diffusion of neuroactive substances in hydrocephalic tissue....

FH - Neurologie, neurochirurgie, neurovědy

  • 2001
  • B
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