Filtry
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats
HI-6 does not influence the therapeutic and reactivating efficacy of the oxime HI-6 against nerve agents. In addition, the higher solubility and stability of HI-6 dimethanesulphonate in compariso...
FP - Ostatní lékařské obory
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Development of novel universal nerve agent antidote based on quaternary cholinesterase reactivators: from substance to autoinjector
filled with HI-6 dimethansulfonate, atropine and diazepam was developed.
KA - Vojenství
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Hyaluronidase: Its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs
Pigs were administered intramuscularly molar equivalents of HI-6 salts (HI-6 dichloride 10.71 mg/kg and HI-6 DMS 13.59 mg/kg) either with or without hyaluronidase (60 discomfort caused by the intr...
FR - Farmakologie a lékárnická chemie
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Transdermal penetration of the acetylcholinesterase reactivator HI-6 in a rat model
The objective of the experiment was to verify that HI-6 dimethanesulphonate (HI organophosphate poisoning using a rat model. HI-6 2Cl is a major component of Transant in the Czech and Slovak armies, althou...
KA - Vojenství
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
New form of HI-6 DCL
New structure of HI-6 having better features for next use.
CC - Organická chemie
- 2007 •
- X
Rok uplatnění
X - Nezařazeno
Direct synthesis of HI-6 DMS in laboratory conditions
Accomplished and verified recepture of HI-6 DMS preparation in laboratory conditions.
CC - Organická chemie
- 2007 •
- Zx
Rok uplatnění
Zx - Nezařazeno - Poloprovoz, ověřená technologie, odrůda, plemeno
Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration
OBJECTIVES: Oxime HI-6 is an acetylcholinesterase reactivator therapeutically the pharmacokinetic profiles of two HI-6 salts after their intravenous (i.v.) administration: Pigs were administered with HI-
FR - Farmakologie a lékárnická chemie
- 2013 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
HPLC analysis of HI-6 dichloride and dimethanesulfonate - Antidotes against nerve agents and organophosphorus pesticides
Description of the simple HPLC method with UV detection for the identification of the acetylcholinesterase reactivator-HI-6 is described. Two salts of HI-6 (dichloride and dimethanesulfonate) were tested. Using thi...
FP - Ostatní lékařské obory
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Investigation of oxidative stress in blood, brain, kidney and liver after oxime antidote HI-6 application in a mouse experimental model
Oxime reactivator HI-6 (asoxime, in some sources) is a potent antidote suitable for treatment of intoxication by nerve agents. Despite the fact that HI-6 is considered for practical application in emergency situati...
FR - Farmakologie a lékárnická chemie
- 2011 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Irinotecan side effects prevented by use of HI-6 oxime:in vivo experimental approach
in chemotherapy, are promising candidates for clinical use. The ability of HI-6 oxime. In this animal study, weinvestigated the efficacy of HI-6 in vivo, when given as a pre and the radical scavenging capacity of ...
FP - Ostatní lékařské obory
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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