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5 926 (0,239s) •

Projekt

Molecular and cellular pharmacology of new conjugated organometalic compound. Relations to development of anticancer drugs. (LD14019)

and understanding of the design and mechanisms of action of new organometalic conjugates, and to use this enhanced knowledge to develop new classes of organometalic compounds. Conjugated organometalic compounds offer such ...

FR - Farmakologie a lékárnická chemie

  • 2014 - 2016
    • •
  • 1 437 tis. Kč
    • •
  • 1 437 tis. Kč
    • •
  • MŠMT
Projekt

Development of Electroanalytical Methods for Interaction of Galectins and Glycomimetic Ligands – New Potential Anticancer Drugs (GA23-06115S)

anticancer drugs based on carbohydrate derivatives. The main goal of this project organometallic galectin ligands, whose synthesis is a part of the project. Together with the basic (spectro)electrochemical characterization of new <...

Organic chemistry

  • 2023 - 2025
    • •
  • 8 775 tis. Kč
    • •
  • 8 775 tis. Kč
    • •
  • GA ČR
Projekt

Bimodal coordination compounds of non-platinum transition metals as a new type of anticancer active substances (GJ17-08512Y)

A project deals with synthesis, characterization and antitumor activity studies of the innovative bimodal complexes of non-platinum transition metals (Ru, Os, Ir), which in one molecule is a key benefit in comparison with conventional an...

CA - Anorganická chemie

  • 2017 - 2019
    • •
  • 3 128 tis. Kč
    • •
  • 3 128 tis. Kč
    • •
  • GA ČR
Projekt

Structure, Properties and the Use of C,N-, Y,C,Y-chelated Organometallic and Related Metal Complexes (GAP207/10/0215)

properties, the structure, the reactivity and possible applications of organometallic C,N-chelated and Y,C,Y-bischelated (Y=N or O) complexes of both transition and main group metals and of analogous metal complexes with Y...

CA - Anorganická chemie

  • 2010 - 2012
    • •
  • 3 737 tis. Kč
    • •
  • 3 737 tis. Kč
    • •
  • GA ČR
Projekt

New platinum (IV) complexes for anticancer therapy (EG15_018/0004605)

New platinum (IV) complexes for anticancer therapy...

FD - Onkologie a hematologie

  • 2015 - 2020
    • •
  • 15 081 tis. Kč
    • •
  • 2 503 tis. Kč
    • •
  • MPO
Projekt

Theoretical calculations of the interaction and properties of the transition metal complexes with biomolecules. (ME10149)

metallodrugs active in the anticancer treatment with models of DNA/RNA (nucleobases chloroligands with water, reaction mechanism of other metal complexes will be explored. This concerns the so called piano?stool ruthenium(II) c...

CF - Fyzikální chemie a teoretická chemie

  • 2010 - 2012
    • •
  • 1 349 tis. Kč
    • •
  • 1 349 tis. Kč
    • •
  • MŠMT
Projekt

Multifunctional organometallic chromophores for light-emitting devices and luminiscent sensors (OC 139)

preparation and investigation of properties of new luminiscent complexes of transient metals...

CF - Fyzikální chemie a teoretická chemie

  • 2006 - 2010
    • •
  • 1 700 tis. Kč
    • •
  • 1 700 tis. Kč
    • •
  • MŠMT
Projekt

Structure and dynamics of organometallic complexes in bio-environment. (GA16-06240S)

on reaction mechanisms and binding selectivity including aspects connected with anticancer...

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2020
    • •
  • 4 989 tis. Kč
    • •
  • 4 188 tis. Kč
    • •
  • GA ČR
Projekt

Advanced immobilized metathesis catalysts for fine chemical synthesis (IAA400400805)

of ruthenium organometallic complexes on the surface of mesoporous sieves. To achieve and textural properties will be optimized. Organometallic complexes will be purchased complexes. Immobilization of the...

CF - Fyzikální chemie a teoretická chemie

  • 2008 - 2012
    • •
  • 4 907 tis. Kč
    • •
  • 4 907 tis. Kč
    • •
  • AV ČR
Projekt

Interactions of organometallic antitumor compounds with nucleic acids and proteins study of sequence and substrate selectivity (GAP208/12/0622)

At present there is a strong request for more potent and less toxic anticancer on the binding of the following complexes to DNA: (1) oxaliplatin, (2) RAPTA-B complex and (3) Os(II) and Rh(III) analogues of RAPTA complex...

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2015
    • •
  • 5 435 tis. Kč
    • •
  • 5 435 tis. Kč
    • •
  • GA ČR
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