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409 (0,099s) •

Projekt

Synthetic multiple antigenic glycopeptides (MAG) containing mucine antigenic determinants - potential diagnostics and cancer vaccines. (GA303/01/0690)

Cancer associated antigen of the mucin type play key-role in the tumour diagnostics. One of the most important glycoprotein structures of this type is MUC-1. This structure contains T, Tn and sialosyl-Tn tumour antigens. In the fram...

EC - Imunologie

  • 2001 - 2003
    • •
  • 4 134 tis. Kč
    • •
  • 3 208 tis. Kč
    • •
  • GA ČR
Projekt

Antidotes against HLA antigens and their importance for formation of chronical rejection. (ME 669)

We presuppose,that we will be able to prove asotiation between occurrence of antisubstance against HLA antigens of donor and chronical rejection of kidneys graft.......

FJ - Chirurgie včetně transplantologie

  • 2003 - 2004
    • •
  • 1 494 tis. Kč
    • •
  • 609 tis. Kč
    • •
  • MŠMT
Projekt

Recombinant antigens for diagnostic kits (OE85)

It is expected that bacterial expression and purification procedure will provide recombinant antigens of diagnostic importance in the standart and uniform qualities. The first commercially interesting antigens are: Glutathione s-tra...

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 8 071 tis. Kč
    • •
  • 3 771 tis. Kč
    • •
  • MŠMT
Projekt

Dendritic antigen-presenting cells in the pathogenesis of psoriasis (NK6005)

Several data of evidence implu that the psoriatic epidermis may harboue unique non-Langerhans antigen-presenting cells (preliminary data indicate CD1a+/-FceRI-DR+CD68+FXIIIa+ subtype of antigen-presenting cell). The continuity of th...

FO - Dermatovenerologie

  • 2000 - 2001
    • •
  • 688 tis. Kč
    • •
  • 688 tis. Kč
    • •
  • MZ
Projekt

Optimized dendritic cells loaded with universal tumor antigens as a potent individualized cancer vaccine (NS9871)

This study aims to prepare a clinical grade cancer vaccine based on optimized dendritic cells loaded with tumor associated antigens tailored for each individual patient.......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 8 171 tis. Kč
    • •
  • 8 171 tis. Kč
    • •
  • MZ
Projekt

Analysis of molecular basis of red cell antigens with respect to prenatal diagnostic of haemolytic disease of the newborn and to solving of transfusion-related problems (NM5952)

Analysis of molecular basis of red cell antigens expression i our population and detailed study of rare and variant antigens with the aim to bring informations useful for clinical implementation of the DNA-based diagnostics. We expe...

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 1 883 tis. Kč
    • •
  • 1 843 tis. Kč
    • •
  • MZ
Projekt

Therapeutic recombinant antigens and monoclonal antibodies - Theramab (FX03030181)

antigens for Covid-19 and AIDS vaccines and the simultaneous development and production of therapeutic monoclonal antibodies (mAbs) using recombinant antigens derived from SARS-CoV-2 and HIV-1. The production of these recombinant p...

Industrial biotechnology

  • 2021 - 2024
    • •
  • 50 861 tis. Kč
    • •
  • 24 419 tis. Kč
    • •
  • MPO
Projekt

Polymer vaccines novel high potent immunostimulants for infectious disseases treatment (GJ16-14957Y)

Safe and efficient vaccine requires, except an antigen, using in the membranes of antigen-presenting cells (APCs), belong to the most efficient ones. However, an antigen and the TLR-agonists. Such polymer vaccines provide b...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 4 624 tis. Kč
    • •
  • 4 624 tis. Kč
    • •
  • GA ČR
Projekt

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

The aim of this project is to find an optimal strategy of T cell stimulation using dendritic cells loaded with different myeloma antigens. Irradiated myeloma cells, myeloma mRNA or peptides derived from tumor associated proteins will be used...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 929 tis. Kč
    • •
  • 6 587 tis. Kč
    • •
  • MZ
Projekt

Von Willebrand factor antigen in necrotizing vasculitis. (IZ2155)

9F - 9

  • 1994 - 1995
    • •
  • 170 tis. Kč
    • •
  • 340 tis. Kč
    • •
  • MZ
  • 1 - 10 z 409