Filtry
Cooperation of both, the FKBP N-like and the DSBA-like, domains is necessary for the correct function of FTS 1067 protein involved in Francisella tularensis virulence and pathogenesis
. holarctica strain FSC200) with homology to the protein family of disulphide isomerases (FKBP N-like). To uncover the biological role of these domains, we created host protective immunity. Analyses performed with the trunc...
EE - Mikrobiologie, virologie
- 2015 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Francisella tularensis subsp holarctica DsbA homologue: a thioredoxin-like protein with chaperone function
with homology to thiol/disulphide oxidoreductase proteins (FtDsbA) is an essential virulence factor in F. tularensis. Its protein sequence has two different domains isomerases (FKBP_N). To establish the role of bo...
EE - Mikrobiologie, virologie
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Mechanisms of anterior gradient-2 regulation and function in cancer
by exquisite catalysts of protein folding, protein disulphide isomerases (PDIs). These enzymes can often provide strict conformational protein folding solutions to highly cysteine-rich cargo as they facil...
FD - Onkologie a hematologie
- 2015 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Mass spectrometry analysis of the oxidation states of the pro-oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond
, and cancer drug-resistance. AGR2 is in the protein-disulphide isomerase superfamily proteins. We have found that mutation of Cysteine-81 attenuates its biochemical that lowlevels of a chemical oxidant promote an ...
EB - Genetika a molekulární biologie
- 2016 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The role of AGR2 and AGR3 in cancer: similar but not identical
In the past decades, highly related members of the protein disulphide isomerase family, anterior gradient protein AGR2 and AGR3, attracted researchers? attention due widely demonstrated as a metastasis-related ...
FD - Onkologie a hematologie
- 2015 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Vibrational and Electronic optical Activity of the Chiral Disulphide Group: Implications for Disulphide Bridge Conformation
The possibility of the assinement of the absolute conformation of the disulphide bridge in the peptides and proteins using various optical activity methods (ECD, VCD, ROA) is ddiscussed. Theoretical approach....
CF - Fyzikální chemie a teoretická chemie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development
in human cancer. AGR2 belongs to the protein disulphide isomerase family with all the key features of an endoplasmic reticulum-resident protein-this gives clues dynamic molecular changes within the cancer cell lan...
FD - Onkologie a hematologie
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Recombinant enzyme haloalkane dehalogenase LinB116 carrying thermostabilizing mutations by FRESCO with removed disulphide bridge.
Recombinant enzyme haloalkane dehalogenase LinB116 carrying mutations for increased protein stability introduced by the methods of protein engineering. Stabilized protein was used for understanding of structure-stability re...
Biological sciences
- 2017 •
- Gfunk
Rok uplatnění
Gfunk - Funkční vzorek
Inhibition of the peptidyl-prolyl-isomerase pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RAR alpha and PML-RAR alpha
The peptidyl-prolyl-isomerase Pin1 interacts with phosphorylated proteins, altering their conformation. The retinoic acid receptor RAR alpha and the acute-promyelocytic-leukemia-specific counterpart PML-RAR alpha directly interact w...
FD - Onkologie a hematologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Spectropohotometric determination of carbon disulphide in the worplace air
The article describes the method for a spectropohotometric determination of carbon disulphide in the worplace air, useable in d?fferent control and monitoring devices....
CB - Analytická chemie, separace
- 2013 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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